{"id":"W4206828660","doi":"10.2196/32401","title":"Identification of Potential Vaccine Candidates Against SARS-CoV-2 to Fight COVID-19: Reverse Vaccinology Approach","year":2021,"lang":"en","type":"article","venue":"JMIR Bioinformatics and Biotechnology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Amity Institute of Biotechnology, Amity University; Amity University","keywords":"Reverse vaccinology; Epitope; Virology; Peptide vaccine; Biology; Antigen; Antigenicity; Major histocompatibility complex; Pandemic; Computational biology; Coronavirus; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Immunology; Disease; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002505134,0.0002722091,0.0003896619,0.0002679491,0.0001499739,0.00005340744,0.0003647204,0.0006151741,0.000007504732],"category_scores_gemma":[0.0002447428,0.0002445363,0.0001085947,0.0004090601,0.00008063205,0.00002315589,0.0005681531,0.0001861215,0.00001547985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002729692,"about_ca_system_score_gemma":0.0001752459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001434902,"about_ca_topic_score_gemma":0.00002108245,"domain_scores_codex":[0.9982316,0.00003282152,0.000894528,0.0003331061,0.0001331162,0.0003748453],"domain_scores_gemma":[0.9985754,0.00001004039,0.0003855775,0.0007512794,0.0001624198,0.0001152773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136931,0.0001424087,0.0002142483,0.0003948561,0.0001324497,0.000004328726,0.0002789424,0.0001023064,0.977627,0.001078801,0.01394597,0.005965046],"study_design_scores_gemma":[0.001329808,0.0003482233,0.0003631961,0.00001600621,0.00004383757,0.0002931354,0.001331126,0.01061807,0.9150317,0.0001471974,0.07007281,0.0004048397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563857,0.000666672,0.03695424,0.004402126,0.0001803426,0.0007023221,0.00015888,0.00006499502,0.0004847392],"genre_scores_gemma":[0.9804457,0.001637395,0.01347018,0.003171144,0.00006768764,0.00007800178,0.0008957882,0.00002805558,0.0002060213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06259521,"threshold_uncertainty_score":0.9971902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223267612953884,"score_gpt":0.2602582499728078,"score_spread":0.2480255738432689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}