{"id":"W4206828660","doi":"10.2196/32401","title":"Identification of Potential Vaccine Candidates Against SARS-CoV-2 to Fight COVID-19: Reverse Vaccinology Approach","year":2021,"lang":"en","type":"article","venue":"JMIR Bioinformatics and Biotechnology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Amity Institute of Biotechnology, Amity University; Amity University","keywords":"Reverse vaccinology; Epitope; Virology; Peptide vaccine; Biology; Antigen; Antigenicity; Major histocompatibility complex; Pandemic; Computational biology; Coronavirus; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Immunology; Disease; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003432203,0.0004425126,0.0007203999,0.000440374,0.0001783941,0.0005932073,0.0003662441,0.0005127337,0.001813631],"category_scores_gemma":[0.0002710424,0.0002159892,0.0007547641,0.0002408405,0.0001992221,0.0006077483,0.0002523734,0.0009560024,0.0005417531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825912,"about_ca_system_score_gemma":0.0003797086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001591551,"about_ca_topic_score_gemma":0.0002711779,"domain_scores_codex":[0.9999001,0.00002053775,0.000005503741,0.00002054253,0.0000271862,0.00002611015],"domain_scores_gemma":[0.9999138,0.00002407573,0.00002193092,0.000007735046,0.00001831325,0.00001408892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000516747,0.0004417683,0.003693408,0.0009417508,0.00009820299,0.0005982908,0.00007674001,0.009954724,0.9397212,0.003182105,0.0006766011,0.04009841],"study_design_scores_gemma":[0.000507887,0.01278648,0.01386524,0.0003703742,0.0008332072,0.004324135,0.0005630793,0.08701189,0.8041129,0.008325833,0.06717922,0.0001199079],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9006075,0.02089682,0.07046859,0.001357689,0.0003255293,0.000627202,0.0007655637,0.0002032419,0.004747852],"genre_scores_gemma":[0.8909829,0.01480739,0.08806189,0.0004741539,0.0001006884,0.0003577989,0.002103079,0.00004140425,0.003070779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813631,"threshold_uncertainty_score":0.006067157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223267612953884,"score_gpt":0.2602582499728078,"score_spread":0.2480255738432689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}