{"id":"W4206897023","doi":"10.1136/jitc-2021-003777","title":"Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET—a phase I, single-arm study","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of Calgary; Université de Montréal; McGill University Health Centre","funders":"National Cancer Institute; GlaxoSmithKline","keywords":"Medicine; Cohort; Endometrial cancer; Internal medicine; Microsatellite instability; Interim analysis; Interim; Oncology; Adverse effect; Cancer; Clinical trial; Biology; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001391759,0.0006378535,0.001394741,0.0002830437,0.0002062336,0.0005935452,0.0003806493,0.0006010153,0.001061537],"category_scores_gemma":[0.0008885111,0.0002575493,0.0007887355,0.0002560699,0.0004576657,0.0005520717,0.0002106654,0.001149425,0.0003508336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005613875,"about_ca_system_score_gemma":0.000541156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001965957,"about_ca_topic_score_gemma":0.0004509653,"domain_scores_codex":[0.9995851,0.000198476,0.00003588776,0.00006860428,0.00005861972,0.00005331394],"domain_scores_gemma":[0.9994265,0.0001354542,0.0001709351,0.00005895654,0.00003277701,0.0001754006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5642649,0.0203171,0.05947364,0.0009776795,0.001605285,0.0004790271,0.000488409,0.005147405,0.09169626,0.0002298392,0.002613273,0.2527071],"study_design_scores_gemma":[0.1693522,0.651706,0.1483562,0.00009262598,0.001349486,0.001494809,0.0001563304,0.004855174,0.01731817,0.0003706573,0.004884257,0.00006410456],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973173,0.001671986,0.0001300779,0.00009983124,0.00001485864,0.0001285622,0.0002026997,0.00002305103,0.0004117423],"genre_scores_gemma":[0.9979759,0.0005420228,0.0002654936,0.0001506022,0.00002894553,0.0001345857,0.0006030528,0.000006778446,0.0002926977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394741,"threshold_uncertainty_score":0.007360399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358148845380517,"score_gpt":0.3416970790202096,"score_spread":0.3081155905664045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}