{"id":"W4206897023","doi":"10.1136/jitc-2021-003777","title":"Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET—a phase I, single-arm study","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of Calgary; Université de Montréal; McGill University Health Centre","funders":"National Cancer Institute; GlaxoSmithKline","keywords":"Medicine; Cohort; Endometrial cancer; Internal medicine; Microsatellite instability; Interim analysis; Interim; Oncology; Adverse effect; Cancer; Clinical trial; Biology; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009664369,0.0004191127,0.001443989,0.0005258995,0.0002894636,0.00003880554,0.0002521416,0.00007145872,0.0007884262],"category_scores_gemma":[0.000263028,0.0002758975,0.0002586705,0.001449191,0.0001581695,0.0002647079,0.0001126839,0.0005096911,1.556541e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001566259,"about_ca_system_score_gemma":0.0007338708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002653707,"about_ca_topic_score_gemma":0.0008908769,"domain_scores_codex":[0.99595,0.0002865042,0.001530156,0.0006759409,0.001028511,0.0005288204],"domain_scores_gemma":[0.996969,0.0005185975,0.001380112,0.0004688364,0.0005005712,0.0001629126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7300828,0.02339357,0.03693705,0.000191321,0.00101693,0.00002558105,0.002748159,0.0001987626,0.014767,0.000001249877,0.00002938182,0.1906082],"study_design_scores_gemma":[0.5854995,0.1685919,0.1400776,0.002078507,0.0009887732,0.00002523761,0.003218872,0.0001045515,0.07855256,0.00004522957,0.01986803,0.0009491899],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850208,0.005663228,0.00003305863,0.0001565875,0.001346044,0.003964665,0.003768836,0.00002688701,0.00001986282],"genre_scores_gemma":[0.9963903,0.002233248,0.0005480464,0.00007528935,0.0001026324,0.0002959307,0.0001072929,0.00006292974,0.0001842781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.189659,"threshold_uncertainty_score":0.9999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358148845380517,"score_gpt":0.3416970790202096,"score_spread":0.3081155905664045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}