{"id":"W4206902780","doi":"10.1172/jci.insight.152638","title":"The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université du Québec; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Centre Hospitalier Universitaire de Québec; Université Laval","keywords":"Lipidome; Immune system; Gut flora; Proinflammatory cytokine; Lipid signaling; Inflammation; Biology; Phospholipase A2; Cell biology; Microbiology; Chemistry; Lipidomics; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760731,0.00009243723,0.00007911331,0.00002358224,0.0003951008,0.00002678412,0.00012701,0.00003849224,0.00002018239],"category_scores_gemma":[0.00002154896,0.00005351378,0.00002839468,0.0000994267,0.00007615268,0.00000536068,0.0001301637,0.0001330167,0.000001563054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002160026,"about_ca_system_score_gemma":0.00007874573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003689958,"about_ca_topic_score_gemma":0.00008429903,"domain_scores_codex":[0.9993748,0.0001014416,0.000147551,0.0001682378,0.00007304594,0.0001349014],"domain_scores_gemma":[0.9995253,0.00002547842,0.000145956,0.0002115447,0.00005767797,0.00003405405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002143649,0.00001863263,0.0001525146,0.00002619252,0.00003451226,7.605502e-7,0.0007321177,0.0000270636,0.9955257,0.00007900645,0.002453378,0.0007357162],"study_design_scores_gemma":[0.0005743868,0.0005615625,0.002000109,0.00001203812,0.00002170755,0.0000624094,0.0006751646,0.00009264316,0.581818,0.000008675644,0.4140569,0.0001163893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960958,0.0009185257,0.00002637238,0.00225978,0.0001403362,0.000328374,0.00001913472,0.000006122182,0.0002055232],"genre_scores_gemma":[0.9988126,0.0001883749,0.0000325624,0.0003056652,0.00008857848,0.00003422069,0.00008681999,0.00001184531,0.0004393705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4137077,"threshold_uncertainty_score":0.3038836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007524487713337192,"score_gpt":0.2276237860725203,"score_spread":0.2200992983591831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}