{"id":"W4206905345","doi":"10.1016/j.celrep.2022.110368","title":"A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de Santé Publique du Québec; McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Mitacs; Canadian Institutes of Health Research; National Institutes of Health; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Effector; Virology; Antibody; Neutralizing antibody; Biology; Epitope; Virus; Neutralization; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005873421,0.0002990139,0.0004747608,0.0003554191,0.0003855592,0.00009271748,0.00009485989,0.0001065359,0.00001668691],"category_scores_gemma":[0.0001275629,0.000271868,0.0001023747,0.0006663743,0.00007191004,0.0001629239,0.0002475797,0.0006097669,0.00002264417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226614,"about_ca_system_score_gemma":0.0003547443,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008309589,"about_ca_topic_score_gemma":0.0003491472,"domain_scores_codex":[0.9973155,0.0001009712,0.0004606795,0.0008690762,0.0007102249,0.0005435221],"domain_scores_gemma":[0.9989138,0.00009611507,0.0002489107,0.0005360834,0.000121556,0.00008358629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008069217,0.0001926756,0.01932689,0.0001580893,0.00008153576,0.004985766,0.00114129,0.00001812613,0.9722322,0.000001149352,0.0002006931,0.000854725],"study_design_scores_gemma":[0.0009920818,0.001157583,0.003005958,0.0001929046,0.0001045049,0.001359422,0.0002255071,0.0001568996,0.9750437,0.00002371687,0.01741848,0.0003192907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922606,0.0002176712,0.001274756,0.00007886629,0.0002564308,0.001551396,0.00001121808,0.0001429102,0.004206148],"genre_scores_gemma":[0.9963297,0.000007128152,0.0004837791,0.00242157,0.0001536051,0.0004143664,0.00002900158,0.00007123462,0.00008956084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01721778,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624452892681592,"score_gpt":0.3245747516258435,"score_spread":0.2983302226990276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}