{"id":"W4206907238","doi":"10.1093/ecco-jcc/jjab232.704","title":"P578 Non-medical switch between adalimumab biosimilars and from the originator adalimumab to biosimilars in inflammatory bowel disease patients – a multicentre study on efficacy and drug sustainability","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Biosimilar; Medicine; Adalimumab; Inflammatory bowel disease; Internal medicine; Ulcerative colitis; Infliximab; Adverse effect; Crohn's disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001385498,0.0002643094,0.000526968,0.0001586019,0.0004267085,0.00007276038,0.0003218107,0.0001383784,0.0001519176],"category_scores_gemma":[0.0007627863,0.0001820116,0.00008920395,0.0001944029,0.0003342965,0.00009058954,0.0003730876,0.0009009949,9.233643e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001680907,"about_ca_system_score_gemma":0.0002609088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001154998,"about_ca_topic_score_gemma":0.00007346457,"domain_scores_codex":[0.997164,0.001005656,0.0007157564,0.0004076666,0.000289274,0.0004176149],"domain_scores_gemma":[0.9978422,0.001166126,0.0002504415,0.000257589,0.0001686594,0.0003149781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007811396,0.001380135,0.9684902,0.00004381067,0.0002974609,0.0003157091,0.003034262,0.000002851596,0.00002268227,0.00004960858,0.003873926,0.01467798],"study_design_scores_gemma":[0.006762674,0.001123552,0.9752542,0.00009065119,0.0001995739,0.00001092093,0.004522643,0.00001010809,0.00005051783,0.0003198608,0.01144242,0.0002128782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868966,0.001187176,0.000006299565,0.01051049,0.000272796,0.0008580434,0.0002501273,0.000007797228,0.00001067669],"genre_scores_gemma":[0.9974866,0.0001166181,0.00003171614,0.002209818,0.00006709946,0.00002401236,0.000006516782,0.0000166423,0.00004097862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144651,"threshold_uncertainty_score":0.7422219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008338829766213253,"score_gpt":0.2768888734724694,"score_spread":0.2685500437062562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}