{"id":"W4206907533","doi":"10.3233/jad-215055","title":"Alzheimer’s Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer’s Disease","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Weston Brain Institute; National Institute on Aging; Alzheimer's Association","keywords":"Genome-wide association study; Genetic architecture; Disease; Genetic association; Biology; Population; Genetics; Alzheimer's disease; Computational biology; Medicine; Gene; Single-nucleotide polymorphism; Genotype; Quantitative trait locus; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006894145,0.001802636,0.001835019,0.03826737,0.001116607,0.005211602,0.00231964,0.001567069,0.03169831],"category_scores_gemma":[0.02347705,0.0009207408,0.001402045,0.04309865,0.0005814697,0.00348662,0.005765927,0.001816386,0.02397547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001008892,"about_ca_system_score_gemma":0.007147359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004701707,"about_ca_topic_score_gemma":0.007663351,"domain_scores_codex":[0.9958298,0.0006933528,0.001702822,0.0007097451,0.0008295671,0.0002347438],"domain_scores_gemma":[0.9722296,0.0110744,0.005131113,0.003149226,0.005259762,0.003155936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009560981,0.0001707913,0.02800687,0.01787873,0.0005381523,0.002042014,0.001266066,0.001162564,0.009019759,0.01096302,0.6859925,0.2420034],"study_design_scores_gemma":[0.0003055321,0.0001084289,0.03132669,0.003207746,0.0004222214,0.001784951,0.000322894,0.0006316444,0.001768844,0.006110366,0.953889,0.0001217807],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.007592291,0.007622943,0.01180174,0.001383265,0.0002588599,0.00070411,0.9523389,0.008070279,0.01022757],"genre_scores_gemma":[0.008577017,0.006144824,0.03902277,0.0006462606,0.0002691755,0.0007328975,0.9402084,0.00201987,0.002378749],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03826737,"threshold_uncertainty_score":0.1060414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787454487929992,"score_gpt":0.2902685180995769,"score_spread":0.262393973220277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}