{"id":"W4206914751","doi":"10.1093/ecco-jcc/jjab232.007","title":"OP08 The effects of maintenance therapy with upadacitinib on abdominal pain, bowel urgency, and fatigue in patients with moderately to severely active Ulcerative Colitis: Phase 3 U-ACHIEVE maintenance results","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Maintenance therapy; Internal medicine; Placebo; Ulcerative colitis; Abdominal pain; Clinical trial; Quality of life (healthcare); Gastroenterology; Clinical endpoint; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001390502,0.0003213809,0.0005866532,0.0001566432,0.0004161488,0.00003833922,0.0003043922,0.000103134,0.00005651306],"category_scores_gemma":[0.000257195,0.0001903965,0.00007233022,0.0003270098,0.0003806737,0.0002097178,0.0001006803,0.001431143,3.355226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830738,"about_ca_system_score_gemma":0.0001709269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000365886,"about_ca_topic_score_gemma":0.0000361419,"domain_scores_codex":[0.996365,0.001801646,0.0005634436,0.0003332424,0.0004468177,0.0004898366],"domain_scores_gemma":[0.996343,0.00217224,0.0006407551,0.0001250476,0.0004271582,0.0002918352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.920864,0.001859427,0.0006026016,0.0000869006,0.0004667564,0.0009754088,0.003103385,0.001255234,0.0002714787,0.0004684276,0.005814258,0.06423209],"study_design_scores_gemma":[0.03987662,0.04206635,0.900962,0.0003104131,0.0001160491,0.0001987662,0.001021293,0.001027772,0.00445198,0.0008176165,0.008699278,0.0004518818],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946163,0.0002665149,0.0000877756,0.002474323,0.0002687419,0.00152916,0.0003439209,0.000008670638,0.0004045471],"genre_scores_gemma":[0.9940544,0.0003022723,0.0001391687,0.005162492,0.00007991105,0.0001394413,0.000007293216,0.00002132684,0.00009368484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9003594,"threshold_uncertainty_score":0.7764145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0371804455587331,"score_gpt":0.3567906425821861,"score_spread":0.319610197023453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}