{"id":"W4206915368","doi":"10.1093/ecco-jcc/jjab232.035","title":"OP36 Efficacy and safety of combination induction therapy with guselkumab and golimumab in participants with moderately-to-severely active Ulcerative Colitis: Results through week 12 of a phase 2a randomized, double-blind, active-controlled, parallel-group, multicenter, proof-of-concept study","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Internal medicine; Clinical endpoint; Golimumab; Gastroenterology; Combination therapy; Surgery; Randomized controlled trial; Tumor necrosis factor alpha; Infliximab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001703084,0.000906017,0.002766976,0.0002884782,0.000509989,0.0006987892,0.0005841152,0.0009749095,0.002861128],"category_scores_gemma":[0.001014932,0.0005174878,0.001314947,0.0003105711,0.0008054429,0.0008153364,0.0004305154,0.001835357,0.0005395632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005018265,"about_ca_system_score_gemma":0.001093808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005350969,"about_ca_topic_score_gemma":0.00115555,"domain_scores_codex":[0.9992905,0.0003299512,0.00005016244,0.0001169703,0.00008147495,0.0001309997],"domain_scores_gemma":[0.9992443,0.0001322157,0.00019085,0.00005656923,0.00005931657,0.0003167721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9355754,0.01826668,0.003046769,0.0003037804,0.0005398033,0.00004278787,0.00007169713,0.0001838637,0.01300444,0.00002881553,0.000278743,0.02865722],"study_design_scores_gemma":[0.3324483,0.6461761,0.01731207,0.00003011714,0.0007708336,0.0000758502,0.00005426355,0.0003699319,0.002073746,0.00005380067,0.000615424,0.00001954352],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972188,0.001359606,0.0002002346,0.0000979183,0.00004511638,0.0006172436,0.0001692346,0.00002327273,0.0002683781],"genre_scores_gemma":[0.996766,0.0006951963,0.0007221001,0.0001403771,0.0001065762,0.0008169293,0.0002165784,0.000005659597,0.0005306032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002861128,"threshold_uncertainty_score":0.009571493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813589145306264,"score_gpt":0.2998586161774069,"score_spread":0.2717227247243442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}