{"id":"W4206922210","doi":"10.1186/s12885-022-09211-1","title":"The mixed blessing of AMPK signaling in Cancer treatments","year":2022,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"AMPK; mTORC1; mTORC2; PI3K/AKT/mTOR pathway; Protein kinase A; Cell biology; Cancer cell; AMP-activated protein kinase; Cancer research; Regulator; Cell growth; Chemistry; Signal transduction; Biology; Kinase; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597658,0.0003814681,0.0004481107,0.0002327407,0.0003405875,0.0008381007,0.0005986003,0.001137507,0.003007175],"category_scores_gemma":[0.001262339,0.0002497587,0.0007925814,0.0002601341,0.0006253604,0.0008178853,0.0006693607,0.0008100862,0.0002737645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007498779,"about_ca_system_score_gemma":0.0009048954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002241543,"about_ca_topic_score_gemma":0.001936085,"domain_scores_codex":[0.9998574,0.00006337503,0.000005937529,0.00002442198,0.0000294596,0.00001936305],"domain_scores_gemma":[0.9997284,0.000163525,0.0000394329,0.00002027477,0.00002626932,0.00002217684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007916152,0.00004309815,0.0007867349,0.0001332637,0.00003469658,0.00009767483,0.00003017529,0.9780096,0.001953258,0.01172456,0.000635132,0.006472527],"study_design_scores_gemma":[0.00004669741,0.0001028421,0.0003997543,0.00003873851,0.00003881684,0.00006085027,0.00003581238,0.9805235,0.001550107,0.01262445,0.004563479,0.00001490363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5604883,0.01276142,0.353939,0.008770161,0.0008870165,0.0002492629,0.00114141,0.0005024298,0.06126099],"genre_scores_gemma":[0.9760381,0.002058406,0.01763608,0.0004381037,0.00005167883,0.0001694487,0.0001660903,0.00004397301,0.003398091],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003007175,"threshold_uncertainty_score":0.01006001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0245349143924635,"score_gpt":0.2977923502153784,"score_spread":0.2732574358229148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}