{"id":"W4206937761","doi":"10.3389/fphar.2021.799034","title":"Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Nasal administration; Dry-powder inhaler; Medicine; Inhalation; Immunogenicity; Adjuvant; Spray drying; ESAT-6; Pharmacology; Tuberculosis; Tuberculosis vaccines; Mycobacterium tuberculosis; Immunology; Antigen; Chromatography; Chemistry; Inhaler; Anesthesia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006228194,0.00081066,0.0005576453,0.0006097343,0.0002119975,0.0003889387,0.0004415666,0.001172381,0.0009146564],"category_scores_gemma":[0.0002654904,0.0003029491,0.0007382326,0.0002432957,0.0004178809,0.0005124151,0.0002174708,0.001387913,0.0004388903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356001,"about_ca_system_score_gemma":0.0002347877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005017477,"about_ca_topic_score_gemma":0.0006938537,"domain_scores_codex":[0.9996056,0.00005467542,0.0000424887,0.0001112528,0.0001274879,0.00005845847],"domain_scores_gemma":[0.9997001,0.00004606562,0.00008296264,0.00005555493,0.00006067819,0.0000547241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191976,0.0001704572,0.00009273946,0.00003412631,0.000006114439,0.00002943497,0.0000143874,0.0001011651,0.9985796,0.00003104135,0.00002150545,0.0008002689],"study_design_scores_gemma":[0.00004143309,0.006172053,0.001269488,0.00001293367,0.00003521445,0.0001647924,0.00002609444,0.0008182593,0.9903055,0.00003887534,0.001107764,0.000007601363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804437,0.001320614,0.01475127,0.0002196639,0.000128478,0.0005357095,0.001187495,0.0002786277,0.001134378],"genre_scores_gemma":[0.9639676,0.002680792,0.02452918,0.0002426017,0.00004443773,0.0008327411,0.001823664,0.00009493828,0.005784015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172381,"threshold_uncertainty_score":0.003293872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02057143254909773,"score_gpt":0.2782859607429499,"score_spread":0.2577145281938522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}