{"id":"W4206940312","doi":"10.1001/jamanetworkopen.2021.44178","title":"Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy","year":2022,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Children's Hospital of Eastern Ontario; Alberta Children's Hospital; University of Saskatchewan; University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute on Disability and Rehabilitation Research; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Duchenne Research Fund; National Institute for Health and Care Research; Parent Project Muscular Dystrophy; National Institute of Neurological Disorders and Stroke; Foundation to Eradicate Duchenne; Children's Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; European Commission; Muscular Dystrophy Association","keywords":"Duchenne muscular dystrophy; Muscular dystrophy; Medicine; Physical medicine and rehabilitation; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002338403,0.0002488806,0.0007980448,0.000306791,0.0002272953,0.0004140669,0.0004144336,0.000778669,0.00149424],"category_scores_gemma":[0.003904174,0.0001425115,0.0005463627,0.0002335294,0.0004148158,0.0003779515,0.000219091,0.0007676021,0.0002307314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600609,"about_ca_system_score_gemma":0.0004496914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005407525,"about_ca_topic_score_gemma":0.0008733756,"domain_scores_codex":[0.9985622,0.0008119835,0.0001567144,0.0001170311,0.0002681215,0.00008394208],"domain_scores_gemma":[0.9968461,0.001022543,0.001413025,0.0001441574,0.0002638256,0.0003103231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4603446,0.01773925,0.1157426,0.002381779,0.001103983,0.0004787177,0.0005455338,0.00120025,0.02981147,0.0001089093,0.001104166,0.3694388],"study_design_scores_gemma":[0.07539477,0.6081717,0.3026458,0.0003620747,0.0006712623,0.0006727661,0.0001963054,0.0009516993,0.008252967,0.0001106795,0.002538409,0.00003152626],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929253,0.005987193,0.000136442,0.0001152282,0.00002741228,0.0001588444,0.0001691382,0.0000158446,0.0004646436],"genre_scores_gemma":[0.9984628,0.0008134496,0.0001595527,0.00006998902,0.00006029433,0.00008935219,0.000133921,0.000001857309,0.0002086782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002338403,"threshold_uncertainty_score":0.01236683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007574053982981234,"score_gpt":0.2407366550315621,"score_spread":0.2331626010485809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}