{"id":"W4206940312","doi":"10.1001/jamanetworkopen.2021.44178","title":"Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy","year":2022,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Children's Hospital of Eastern Ontario; Alberta Children's Hospital; University of Saskatchewan; University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute on Disability and Rehabilitation Research; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Duchenne Research Fund; National Institute for Health and Care Research; Parent Project Muscular Dystrophy; National Institute of Neurological Disorders and Stroke; Foundation to Eradicate Duchenne; Children's Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; European Commission; Muscular Dystrophy Association","keywords":"Duchenne muscular dystrophy; Muscular dystrophy; Medicine; Physical medicine and rehabilitation; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004175348,0.00008777779,0.0001726958,0.00001858514,0.0001071904,0.00001060824,0.0003172098,0.00006901119,0.0001088073],"category_scores_gemma":[0.00003511304,0.00009129484,0.00003398149,0.0001265337,0.0000666808,0.000004454357,0.0008853231,0.000134418,0.000001005189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006545545,"about_ca_system_score_gemma":0.00003512936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001066754,"about_ca_topic_score_gemma":0.00003427073,"domain_scores_codex":[0.9991009,0.0002089034,0.000180003,0.0002635931,0.00005852132,0.0001880322],"domain_scores_gemma":[0.9995897,0.00002298442,0.00007469003,0.000260411,0.00001522216,0.00003693592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05361018,0.002128527,0.1847563,0.0001689426,0.0009492961,0.00008102222,0.001000888,0.2506925,0.3872206,0.008849452,0.04879216,0.06175015],"study_design_scores_gemma":[0.01128384,0.001699804,0.8586042,0.00003313608,0.00003700566,0.00001673104,0.0002658842,0.0004769276,0.001659492,0.001747475,0.1237167,0.0004588719],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961759,0.001410481,0.00004035803,0.0003597978,0.00006979785,0.0003322529,0.0000123619,0.000002677461,0.001596331],"genre_scores_gemma":[0.9986946,0.0002193051,0.0002600249,0.0004351995,0.00009219509,0.00005508927,0.0001359274,0.00001078796,0.00009689754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6738479,"threshold_uncertainty_score":0.3722895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007574053982981234,"score_gpt":0.2407366550315621,"score_spread":0.2331626010485809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}