{"id":"W4206943819","doi":"10.1093/oncolo/oyac031","title":"Optimism Bias in the Design of Phase III Randomized Control Trials Evaluating PD-1/PD-L1 Targeting Monoclonal Antibodies","year":2022,"lang":"en","type":"review","venue":"The Oncologist","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Hazard ratio; Monoclonal antibody; Confidence interval; Internal medicine; Optimism; Randomized controlled trial; Clinical endpoint; Oncology; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.0784402,0.0005275398,0.007119113,0.0002099747,0.0002722171,0.00004718182,0.000728822,0.0002555348,0.0009831549],"category_scores_gemma":[0.01158637,0.0002293531,0.001940285,0.0005166251,0.0008478978,0.00003710839,0.00009276616,0.0009097179,0.000004282281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005202105,"about_ca_system_score_gemma":0.001854353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003549668,"about_ca_topic_score_gemma":0.000004948804,"domain_scores_codex":[0.9761591,0.01917415,0.003088354,0.0004133935,0.0007466516,0.0004183714],"domain_scores_gemma":[0.9546295,0.04136397,0.003243656,0.0006341208,0.0000864835,0.00004222089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2188824,0.0004937508,7.83798e-7,0.001879781,0.002285887,0.00006673655,0.001113796,0.0001368439,0.0001114679,0.00003288842,0.003512896,0.7714827],"study_design_scores_gemma":[0.4291311,0.001618605,0.000001013247,0.003868275,0.008956073,0.0001305525,0.0009468998,0.001601777,0.000008636347,0.00008357445,0.5532916,0.0003618856],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001169523,0.9855236,0.0006976263,0.0007083729,0.0006166543,0.01102391,0.00008759916,0.00003468598,0.001190538],"genre_scores_gemma":[0.0004562111,0.9948089,0.001059731,0.0005668266,0.0004256946,0.002014474,0.0001426748,0.00004679878,0.0004786707],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7711208,"threshold_uncertainty_score":0.9999301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4502228749374113,"score_gpt":0.5122209442929506,"score_spread":0.06199806935553936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}