{"id":"W4206943819","doi":"10.1093/oncolo/oyac031","title":"Optimism Bias in the Design of Phase III Randomized Control Trials Evaluating PD-1/PD-L1 Targeting Monoclonal Antibodies","year":2022,"lang":"en","type":"review","venue":"The Oncologist","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Hazard ratio; Monoclonal antibody; Confidence interval; Internal medicine; Optimism; Randomized controlled trial; Clinical endpoint; Oncology; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7309018,0.003034152,0.01033386,0.00831248,0.001778668,0.009562989,0.005150746,0.006758519,0.005125017],"category_scores_gemma":[0.7954553,0.003188517,0.01307398,0.007684316,0.007262369,0.008580839,0.004466859,0.005732404,0.001404413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006118793,"about_ca_system_score_gemma":0.00847849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008062035,"about_ca_topic_score_gemma":0.001422381,"domain_scores_codex":[0.1224038,0.7213327,0.1113367,0.01769585,0.02570329,0.001527529],"domain_scores_gemma":[0.07965395,0.8196204,0.05401151,0.032573,0.01324821,0.0008929293],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03947288,0.0004779612,0.04478912,0.3711778,0.09886666,0.001169313,0.009126936,0.007660187,0.002655457,0.06677397,0.02890694,0.3289228],"study_design_scores_gemma":[0.05246309,0.009927565,0.04410687,0.2260105,0.1188265,0.002375124,0.002380013,0.02996635,0.008173725,0.3319651,0.1723786,0.001426659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.04442837,0.3458993,0.4493196,0.04691064,0.01820477,0.06557941,0.005617365,0.001641361,0.02239911],"genre_scores_gemma":[0.5125445,0.02153412,0.3131432,0.03353843,0.005231012,0.1094115,0.00222184,0.0004515573,0.001923984],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.2690982,"threshold_uncertainty_score":0.331846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4502228749374113,"score_gpt":0.5122209442929506,"score_spread":0.06199806935553936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}