{"id":"W4206944818","doi":"10.1136/jitc-2021-003024","title":"Defining unique clinical hallmarks for immune checkpoint inhibitor-based therapies","year":2022,"lang":"en","type":"review","venue":"Journal for ImmunoTherapy of Cancer","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Medicine; Oncology; Adverse effect; Immunotherapy; Internal medicine; Cancer; Immune system; Quality of life (healthcare); Intensive care medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00292236,0.0005647253,0.00343653,0.0002961992,0.0003264528,0.0000482545,0.0003067614,0.0003333348,0.001316572],"category_scores_gemma":[0.000156231,0.0003894557,0.005071636,0.0001991645,0.0001333943,0.00005646895,0.00002883485,0.000962575,0.000001154584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005753782,"about_ca_system_score_gemma":0.002553868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004786031,"about_ca_topic_score_gemma":0.000006638337,"domain_scores_codex":[0.9959391,0.0003367727,0.002477279,0.0003852685,0.0004230191,0.0004385026],"domain_scores_gemma":[0.9951706,0.001584921,0.002343782,0.0005117288,0.0002576857,0.0001312729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00198932,0.0005004753,0.00002176317,0.006323756,0.005518985,0.00001165185,0.00006615646,0.000005782481,0.00001190532,0.0001497563,0.001237849,0.9841626],"study_design_scores_gemma":[0.008089601,0.003538485,0.00002628864,0.01047586,0.002582648,0.0001223711,0.00005539744,0.00001197494,0.00006822879,0.000165773,0.9745309,0.0003324077],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004984911,0.9924239,0.001305527,0.0006071017,0.00221453,0.002833966,0.0004862272,0.00002373655,0.00005518368],"genre_scores_gemma":[0.0000143155,0.985294,0.01059876,0.0004292867,0.0007452099,0.001772494,0.0002628392,0.0002179472,0.0006651892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9838302,"threshold_uncertainty_score":0.9998558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.10129871765779,"score_gpt":0.4582339463718856,"score_spread":0.3569352287140957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}