{"id":"W4206947552","doi":"10.1093/ecco-jcc/jjab232.738","title":"P612 Mirikizumab Pharmacokinetics and Exposure - Efficacy Relationships in Patients with Ulcerative Colitis","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Pharmacokinetics; Placebo; Population; Internal medicine; Gastroenterology; Volume of distribution; Psoriasis; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003382089,0.0003635123,0.0009697376,0.0002819803,0.0001722761,0.0008552276,0.0002015709,0.0005874246,0.001724611],"category_scores_gemma":[0.00938537,0.0003130751,0.0007235614,0.0004153217,0.0002405495,0.0006397665,0.0002946092,0.0007636648,0.0002365504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003258854,"about_ca_system_score_gemma":0.0003314773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004108388,"about_ca_topic_score_gemma":0.0003019057,"domain_scores_codex":[0.9979954,0.001319546,0.0001271765,0.0002601052,0.0001943594,0.0001034714],"domain_scores_gemma":[0.9932266,0.004516801,0.001536416,0.0003087007,0.0001598098,0.0002516435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03536154,0.001082232,0.8808011,0.0004278705,0.002082015,0.0006998066,0.000280542,0.008837868,0.007650434,0.0003131366,0.0008437086,0.06161978],"study_design_scores_gemma":[0.001513447,0.0142196,0.9512465,0.0000451853,0.001097068,0.00123187,0.0001150445,0.02602933,0.001831468,0.0009264125,0.001700367,0.00004360505],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950334,0.002342107,0.001568374,0.0001867596,0.00001046316,0.00002843839,0.000204099,0.00003821173,0.0005882381],"genre_scores_gemma":[0.999225,0.0001486582,0.0003444632,0.00004981782,0.00001472647,0.00001382529,0.00009664299,0.000004256073,0.0001025406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003382089,"threshold_uncertainty_score":0.0178864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885732158269787,"score_gpt":0.2679036466300737,"score_spread":0.2490463250473758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}