{"id":"W4206947583","doi":"10.1101/2022.01.21.477187","title":"Reconstitution of an active human CENP-E motor","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Wellcome Trust","keywords":"Microtubule; Mitosis; Xenopus; Motor protein; Molecular motor; Kinesin; Cell biology; Biology; Processivity; Chromosome segregation; Motility; In vitro; Chromosome; Genetics; DNA; Gene; DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003384087,0.000416405,0.0002399814,0.0002515981,0.0002065682,0.0004117792,0.0004728594,0.0003855349,0.001161422],"category_scores_gemma":[0.0003151877,0.000241173,0.0002555643,0.0003286328,0.000285139,0.0002309185,0.0004265017,0.0006579875,0.0006686453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006268991,"about_ca_system_score_gemma":0.0002672993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001375341,"about_ca_topic_score_gemma":0.0009321736,"domain_scores_codex":[0.9997846,0.00004610309,0.00003428255,0.00005225261,0.0000469817,0.0000357163],"domain_scores_gemma":[0.9998519,0.00004098299,0.00003159213,0.00003265917,0.00001406,0.00002878727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002155566,0.00009379067,0.0003257267,0.00008179312,0.00002770451,0.0001130971,0.00004416168,0.0007321076,0.9961864,0.0007813706,0.0001514507,0.001246864],"study_design_scores_gemma":[0.00005567047,0.0001350235,0.001921185,0.00001837332,0.00001758969,0.0001486147,0.00003673675,0.004366029,0.985508,0.0001399395,0.007641765,0.00001095586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989242,0.001031398,0.00648396,0.0001387931,0.00006589646,0.00005506291,0.001501588,0.0001585891,0.001322695],"genre_scores_gemma":[0.9855981,0.0004794878,0.005436764,0.00003141382,0.00000858431,0.00005516237,0.004112443,0.00007824356,0.004199799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375341,"threshold_uncertainty_score":0.00454843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104610192906067,"score_gpt":0.2343786092468159,"score_spread":0.2233325073177553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}