{"id":"W4206951220","doi":"10.1093/ecco-jcc/jjab232.081","title":"DOP42 Efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with moderately-to-severely active Ulcerative Colitis: 12-week results from the Phase 2 LATTICE-UC study","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Ulcerative colitis; Clinical endpoint; Gastroenterology; Placebo; Adverse effect; Concomitant; Phases of clinical research; Clinical trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001091276,0.0008697489,0.002154634,0.0002453861,0.0002784743,0.0008460226,0.0004368043,0.0009984376,0.002900938],"category_scores_gemma":[0.0008605332,0.0003797098,0.001347997,0.0002386454,0.0004708156,0.0006152467,0.0003162562,0.001843711,0.0005102122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477314,"about_ca_system_score_gemma":0.0006286722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005790427,"about_ca_topic_score_gemma":0.001735708,"domain_scores_codex":[0.9995891,0.0002260528,0.00002827381,0.00006169246,0.00003727953,0.0000575652],"domain_scores_gemma":[0.9994403,0.0001142392,0.0001421278,0.00003173263,0.00004273531,0.0002288485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8827636,0.01244037,0.005796295,0.001071419,0.001641186,0.0001731964,0.0001166858,0.001220885,0.02869009,0.00008165473,0.00218123,0.06382341],"study_design_scores_gemma":[0.6568057,0.3085343,0.02597358,0.00007266938,0.001148554,0.0003086395,0.00007601673,0.001190268,0.002958695,0.0001210449,0.002764224,0.00004639817],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900784,0.006833661,0.0001937536,0.0003091156,0.00009368938,0.0004129028,0.0008834462,0.00005530611,0.001139658],"genre_scores_gemma":[0.9950715,0.001547168,0.0003701599,0.0003440205,0.0001210402,0.0002888132,0.001149988,0.00001021861,0.001097174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002900938,"threshold_uncertainty_score":0.00970459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148149313829524,"score_gpt":0.2559181814174536,"score_spread":0.2444366882791584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}