{"id":"W4206962479","doi":"10.1093/neuonc/noac021","title":"Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Thompson Rivers University; University Health Network","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Biology; Transcriptome; Seminoma; Germ cell tumors; Phenotype; Tumor microenvironment; Germ cell; Atypical teratoid rhabdoid tumor; Embryonic stem cell; Germinoma; Cancer research; Pathology; Immune system; Immunology; Genetics; Gene expression; Immunohistochemistry; Gene; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147556,0.0001565525,0.0001984705,0.0005961523,0.0001815603,0.000189563,0.0001138883,0.0001280617,0.0008336163],"category_scores_gemma":[0.0002011999,0.00007288172,0.0002109181,0.0005678548,0.0001221112,0.0001166105,0.0001958167,0.0001477402,0.0001586872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518429,"about_ca_system_score_gemma":0.0001907537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001124968,"about_ca_topic_score_gemma":0.002492856,"domain_scores_codex":[0.9998912,0.000008870585,0.000006479735,0.00004275483,0.00002897794,0.0000217816],"domain_scores_gemma":[0.9998956,0.00001577326,0.00003730771,0.0000104192,0.00002484312,0.00001610908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002563875,0.00001670812,0.1505959,0.0001266975,0.00009328708,0.0003407794,0.0002019828,0.0002283798,0.8334813,0.00008724999,0.0001631631,0.01440824],"study_design_scores_gemma":[0.000006534046,0.0002043799,0.8743793,0.00001908977,0.0001845651,0.002257317,0.0003192102,0.001478091,0.1178316,0.0002035167,0.003104489,0.00001182773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944535,0.0009639624,0.002023735,0.00002829716,0.000005295499,0.00001287205,0.001843772,0.00003092285,0.0006376028],"genre_scores_gemma":[0.9928745,0.0007239435,0.002755414,0.00003089988,0.00000576448,0.00003222173,0.002888219,0.0000154696,0.0006736379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124968,"threshold_uncertainty_score":0.002788782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143386340365782,"score_gpt":0.2788781851748157,"score_spread":0.2574443217711578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}