{"id":"W4206962479","doi":"10.1093/neuonc/noac021","title":"Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Thompson Rivers University; University Health Network","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Biology; Transcriptome; Seminoma; Germ cell tumors; Phenotype; Tumor microenvironment; Germ cell; Atypical teratoid rhabdoid tumor; Embryonic stem cell; Germinoma; Cancer research; Pathology; Immune system; Immunology; Genetics; Gene expression; Immunohistochemistry; Gene; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002727135,0.00019719,0.001050528,0.0006728334,0.00005989915,0.00000771292,0.00007616759,0.0000606625,0.0001908604],"category_scores_gemma":[0.00005681082,0.0001680038,0.0001074534,0.0008090372,0.0001132601,0.00004268262,0.00005860408,0.0001611873,3.595585e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009895666,"about_ca_system_score_gemma":0.0001507069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008871597,"about_ca_topic_score_gemma":0.00007270501,"domain_scores_codex":[0.9983952,0.0002345891,0.0004607922,0.0003941389,0.0002708082,0.000244496],"domain_scores_gemma":[0.998656,0.0006802366,0.0002344049,0.0002243025,0.0000860857,0.0001190088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002818035,0.001060356,0.3833794,0.0002384706,0.0003224732,0.001236991,0.001027632,0.0003696493,0.6117488,0.00002113177,0.0001329323,0.0001804003],"study_design_scores_gemma":[0.01068105,0.008844869,0.7610638,0.00008010991,0.008254636,0.0002392102,0.001548132,0.001475188,0.2022119,0.00002221868,0.005198048,0.0003808124],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955261,0.002828992,0.000003319078,0.0005042104,0.00005243111,0.0004602531,0.0002960769,0.0000124414,0.0003162115],"genre_scores_gemma":[0.9987431,0.0002108849,0.0002278817,0.0005235326,0.000008562009,0.0001886415,0.00004418498,0.00002222885,0.00003094682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4095369,"threshold_uncertainty_score":0.6850995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143386340365782,"score_gpt":0.2788781851748157,"score_spread":0.2574443217711578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}