{"id":"W4206973472","doi":"10.1186/s12864-022-08306-0","title":"Neural transcriptomic signature of chronic wasting disease in white-tailed deer","year":2022,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Agriculture and Agri-Food Canada","funders":"Alberta Prion Research Institute; University of Alberta; Legislative-Citizen Commission on Minnesota Resources; Génome Québec; Western Canada Research Grid; Genome Alberta; Minnesota Environment and Natural Resources Trust Fund; Alberta Agriculture and Forestry; Genome Canada; Canadian Food Inspection Agency; Compute Canada","keywords":"Biology; Chronic wasting disease; Transcriptome; RNA-Seq; Odocoileus; Gene; Genome; Genetics; Disease; KEGG; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373406,0.0002162999,0.0002456864,0.0006572736,0.0001779123,0.0004016422,0.00009269961,0.000256227,0.000584422],"category_scores_gemma":[0.0001735258,0.00007265431,0.0002316378,0.0004315118,0.0002266703,0.0001293246,0.0001940958,0.0002425638,0.000153921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001204804,"about_ca_system_score_gemma":0.0001134605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004785602,"about_ca_topic_score_gemma":0.001127402,"domain_scores_codex":[0.9998769,0.00001159138,0.000009936545,0.00005024887,0.00002461315,0.000026818],"domain_scores_gemma":[0.9998665,0.00002195694,0.00005171732,0.00000733251,0.00002904758,0.00002334462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006087375,0.00005009165,0.105722,0.0002828383,0.0001045611,0.0003711862,0.0001961207,0.0002249144,0.8872589,0.00007795087,0.000250594,0.004852008],"study_design_scores_gemma":[0.00001552433,0.0004776408,0.9655254,0.00006275714,0.000143624,0.00134783,0.0006629559,0.001167973,0.02806542,0.0002731282,0.00223974,0.00001795452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959274,0.0007507841,0.0005593154,0.00002649442,0.000009766227,0.0000164966,0.002358674,0.00001081506,0.0003402988],"genre_scores_gemma":[0.9888765,0.001010391,0.002425615,0.0001339885,0.00001962231,0.00008012626,0.006581842,0.000008980911,0.0008629025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006572736,"threshold_uncertainty_score":0.001955092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009868802656902877,"score_gpt":0.2237357572292415,"score_spread":0.2138669545723386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}