{"id":"W4206974688","doi":"10.7554/elife.72452.sa2","title":"Author response: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Disease; Obesity; Internal medicine; Metabolic syndrome; Mendelian randomization; Adverse effect; Diabetes mellitus; Coronary artery disease; Kidney disease; Polycystic ovary; Endocrinology; Insulin resistance; Biology; Genetic variants; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03970998,0.001254973,0.002094402,0.001456472,0.0008735479,0.002038259,0.001927728,0.007781144,0.1283231],"category_scores_gemma":[0.3196428,0.001027234,0.002595819,0.001712269,0.001004553,0.001697293,0.001501259,0.005651778,0.03448754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001942051,"about_ca_system_score_gemma":0.003355272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002258688,"about_ca_topic_score_gemma":0.002454305,"domain_scores_codex":[0.9576852,0.03037778,0.005089026,0.00209293,0.003854239,0.0009007994],"domain_scores_gemma":[0.7736837,0.1685822,0.009681884,0.01068682,0.03425392,0.003111435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008024405,0.00002439418,0.0006907479,0.0007304914,0.00009125892,0.00008662869,0.00004587177,0.0001746836,0.00005560943,0.001092795,0.9835792,0.01262595],"study_design_scores_gemma":[0.006305913,0.0004872308,0.006211758,0.003742813,0.0004648138,0.0005309399,0.0003411461,0.002619736,0.000782206,0.01609051,0.9621433,0.0002796157],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.003325823,0.002927504,0.02827461,0.5440202,0.3455126,0.00863738,0.0276072,0.003963935,0.0357306],"genre_scores_gemma":[0.05182775,0.003410593,0.04242876,0.6782794,0.09107918,0.02673981,0.007867818,0.002547215,0.09581946],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1283231,"threshold_uncertainty_score":0.4292837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0390478417873103,"score_gpt":0.3421675806301817,"score_spread":0.3031197388428714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}