{"id":"W4206984086","doi":"10.1101/2022.01.19.476693","title":"SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Alberta; University of Manitoba; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Children's Hospital of Eastern Ontario; Christie (Canada); McGill University","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; China Scholarship Council; Directorate for Biological Sciences; Terry Fox Research Institute; National Research Foundation of Korea; Queen's University; National Research Foundation","keywords":"Messenger RNA; Translation (biology); Innate immune system; Interferon; Psychological repression; Biology; Cell biology; Immune system; Protein biosynthesis; microRNA; Virology; RNA; Mechanism (biology); Immunology; Gene expression; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000947764,0.0006019466,0.0008254687,0.0005548868,0.0002612636,0.00003689526,0.0006791193,0.0008599913,0.0004735548],"category_scores_gemma":[0.0002295613,0.0006264043,0.0003396152,0.0003688645,0.0001875196,0.0001889528,0.0005460132,0.001551799,0.000109349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335111,"about_ca_system_score_gemma":0.0003587551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001815169,"about_ca_topic_score_gemma":0.000003301164,"domain_scores_codex":[0.9962654,0.0009093391,0.001001056,0.001132857,0.0001517261,0.0005395999],"domain_scores_gemma":[0.9971128,0.0000846666,0.000846043,0.001571392,0.0003527208,0.00003241184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001402139,0.0003166791,0.0002821624,0.0002731357,0.0003230269,0.000007390129,0.0001159484,0.00002001744,0.9965855,0.00003571863,0.0005843861,0.0000538735],"study_design_scores_gemma":[0.0007387436,0.0004806627,0.006438516,0.0004705536,0.000153455,2.117196e-7,0.00001963857,0.00002728895,0.9852297,0.000001653581,0.005864271,0.0005753505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873586,0.004523168,0.0004247158,0.0002251649,0.005983938,0.0009920152,0.0001114399,0.0003531253,0.00002788005],"genre_scores_gemma":[0.9989481,0.000230998,0.0002513604,0.00007872419,0.0001217232,0.0002091327,0.000004978223,0.0001191723,0.00003578964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01158957,"threshold_uncertainty_score":0.9996187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02908490339003329,"score_gpt":0.2609406755543697,"score_spread":0.2318557721643364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}