{"id":"W4206986038","doi":"10.1097/shk.0000000000001915","title":"Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis","year":2022,"lang":"en","type":"article","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute","keywords":"Sepsis; Immune system; Ex vivo; In vivo; Inflammation; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004684861,0.0002294502,0.0002886428,0.0007658208,0.000148274,0.0003277767,0.0001425143,0.0002215277,0.001044035],"category_scores_gemma":[0.0008004553,0.00007559667,0.0001927006,0.0006185969,0.000240058,0.0001797147,0.0002754595,0.000240488,0.0002263517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576476,"about_ca_system_score_gemma":0.0001352347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001442506,"about_ca_topic_score_gemma":0.0001474319,"domain_scores_codex":[0.9997969,0.00006536909,0.0000188734,0.00004881774,0.00003722321,0.00003292619],"domain_scores_gemma":[0.9994988,0.0001577987,0.0001785902,0.00003313754,0.00007818296,0.00005346891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003143971,0.0002047307,0.2292884,0.0006372088,0.0001513427,0.0005623219,0.0004282538,0.001633236,0.7376531,0.00035676,0.0002973263,0.02564333],"study_design_scores_gemma":[0.00004600896,0.001538197,0.9203379,0.00009222389,0.0001726883,0.001870249,0.0004688971,0.003097755,0.0690244,0.000924492,0.002397551,0.00002970669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952796,0.001290442,0.001949871,0.00006211684,0.000006175667,0.00001577734,0.00112805,0.000009485069,0.0002585131],"genre_scores_gemma":[0.995753,0.0008171471,0.001329227,0.00005144879,0.00002558346,0.00005441891,0.001724641,0.000005920203,0.0002384565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044035,"threshold_uncertainty_score":0.003492653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772884183341215,"score_gpt":0.2697583753622855,"score_spread":0.2420295335288734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}