{"id":"W4206986038","doi":"10.1097/shk.0000000000001915","title":"Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis","year":2022,"lang":"en","type":"article","venue":"Shock","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute","keywords":"Sepsis; Immune system; Ex vivo; In vivo; Inflammation; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003899171,0.00008918961,0.0002276856,0.0001776089,0.0002227837,0.000003140984,0.00007966696,0.0000469714,0.0002933744],"category_scores_gemma":[0.00004143528,0.0000898228,0.00005552641,0.0001230349,0.0001328665,0.00007248387,0.00006118701,0.0001982758,0.00001649854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003363752,"about_ca_system_score_gemma":0.00003333453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074191,"about_ca_topic_score_gemma":0.00002483048,"domain_scores_codex":[0.9989659,0.0003782314,0.0003268132,0.0001448056,0.00003595202,0.0001483373],"domain_scores_gemma":[0.9996164,0.0001407317,0.0000817234,0.0001282823,0.00002848988,0.000004352163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001394315,0.00004175045,0.003426645,0.00001847459,0.00009094069,0.000002971987,0.002827012,0.00003078319,0.9901001,0.0008740659,0.0003904756,0.0008024562],"study_design_scores_gemma":[0.002518499,0.0004942397,0.3268701,0.00003341303,0.00002544249,0.00004139756,0.002255937,0.000004400146,0.6581711,0.0003756867,0.00904974,0.0001600546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836656,0.01548295,0.000007463588,0.0002132351,0.000273659,0.0001485757,0.00001522122,0.00001704041,0.0001761939],"genre_scores_gemma":[0.9959083,0.0001288921,0.00001129605,0.00004030067,0.000007187236,0.00004480688,0.00002518937,0.000007144292,0.003826901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3319291,"threshold_uncertainty_score":0.3662868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772884183341215,"score_gpt":0.2697583753622855,"score_spread":0.2420295335288734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}