{"id":"W4206991479","doi":"10.1016/j.intimp.2022.108523","title":"In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development","year":2022,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Bradykinin; Icatibant; Bradykinin receptor; Receptor; Receptor antagonist; Antagonist; Potency; Pharmacology; Chemistry; In vitro; Competitive antagonist; Agonist; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003843218,0.00053185,0.0004906565,0.0002342734,0.000202546,0.000577169,0.0002964262,0.000375211,0.003736679],"category_scores_gemma":[0.0004793859,0.0002268235,0.0002744241,0.0002267922,0.0001346847,0.0002286776,0.0001291161,0.0008477006,0.001655358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235232,"about_ca_system_score_gemma":0.0003127458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000687744,"about_ca_topic_score_gemma":0.000952278,"domain_scores_codex":[0.9996727,0.0001564878,0.00002038763,0.0000295973,0.0000734004,0.0000475033],"domain_scores_gemma":[0.9997733,0.00005929383,0.00003487899,0.00002396306,0.00005092943,0.00005761003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0016792,0.0006960576,0.0005466807,0.0002177088,0.00004263683,0.0002217287,0.00005061733,0.0003990627,0.9768944,0.0001028841,0.00088076,0.01826831],"study_design_scores_gemma":[0.001269922,0.0515334,0.02307978,0.00005492734,0.0004528041,0.003769049,0.0001554197,0.003390798,0.8801717,0.0001545114,0.03592582,0.00004191591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477717,0.0263202,0.008842475,0.0007858969,0.0001895392,0.0004532263,0.002908375,0.0001776225,0.01255098],"genre_scores_gemma":[0.9670736,0.01329471,0.004811413,0.0003996885,0.0002040497,0.0003364687,0.00611362,0.00005734788,0.007709147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003736679,"threshold_uncertainty_score":0.01250041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867313413097972,"score_gpt":0.359735346148004,"score_spread":0.3210622120170243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}