{"id":"W4206991479","doi":"10.1016/j.intimp.2022.108523","title":"In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development","year":2022,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Bradykinin; Icatibant; Bradykinin receptor; Receptor; Receptor antagonist; Antagonist; Potency; Pharmacology; Chemistry; In vitro; Competitive antagonist; Agonist; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001010305,0.0002281526,0.0005785052,0.0004591162,0.00008933667,0.00001084517,0.000442503,0.000121091,0.007880128],"category_scores_gemma":[0.0001184823,0.0002415445,0.0001803161,0.0003995581,0.0001817569,0.00009779415,0.0004096531,0.0006785872,0.00005157034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000513849,"about_ca_system_score_gemma":0.0005726505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001186971,"about_ca_topic_score_gemma":0.00001176586,"domain_scores_codex":[0.9969056,0.000376702,0.001421907,0.0004915412,0.0004082067,0.0003960157],"domain_scores_gemma":[0.9989463,0.0003198254,0.0003551311,0.000136359,0.0001372259,0.0001051454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01005383,0.005034625,0.05451358,0.0000405409,0.0005507583,0.0007666373,0.0008503426,0.0001732783,0.906459,0.0002881369,0.00605392,0.0152153],"study_design_scores_gemma":[0.02471582,0.000978543,0.186136,0.0000542554,0.0001246649,0.0002767718,0.0004236724,0.006085356,0.6567914,0.0001019199,0.1237257,0.0005859364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912681,0.0006949246,0.00002681228,0.003088829,0.002511119,0.0006873445,0.00006530684,0.00004125912,0.001616279],"genre_scores_gemma":[0.992382,0.0001269534,0.001182688,0.003031016,0.0002366866,0.0004113847,0.0003355404,0.00003014651,0.002263564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2496677,"threshold_uncertainty_score":0.9930268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867313413097972,"score_gpt":0.359735346148004,"score_spread":0.3210622120170243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}