{"id":"W4206994211","doi":"10.3390/cells11030380","title":"From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Ubiquitin ligase; Ubiquitin; Proteostasis; Biology; Proteasome; Ubiquitin-Protein Ligases; Cell biology; Endoplasmic reticulum; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002640878,0.0007447316,0.0007785937,0.001657646,0.0002217832,0.0006718641,0.0006316936,0.0007878416,0.002066569],"category_scores_gemma":[0.0002983024,0.0001974091,0.0003253533,0.001507542,0.0004738222,0.0008904579,0.0005500831,0.001385545,0.001696842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006508627,"about_ca_system_score_gemma":0.000632201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133284,"about_ca_topic_score_gemma":0.001396507,"domain_scores_codex":[0.9998966,0.00001472256,0.00001684245,0.00002576085,0.00003331016,0.00001282833],"domain_scores_gemma":[0.999931,0.00002520906,0.00001081489,0.000003169635,0.00001926609,0.00001047962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001098287,0.00003559669,0.000287916,0.01100165,0.00006558783,0.000423857,0.00007166796,0.0002916894,0.004488078,0.005699095,0.04363958,0.9338855],"study_design_scores_gemma":[0.00001098014,0.0000439433,0.0008235084,0.00101631,0.00004848704,0.001887042,0.00002753381,0.00004439849,0.0006752054,0.001356012,0.9940569,0.000009677027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000133235,0.9985058,0.00009121563,0.00018456,0.0001458172,0.000001875316,0.00001503016,0.000005796208,0.0009167094],"genre_scores_gemma":[0.0009760046,0.9976761,0.0001516043,0.0002587115,0.0001326335,0.000003406171,0.00003871814,0.000001697779,0.0007610285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002066569,"threshold_uncertainty_score":0.006913424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390694501670963,"score_gpt":0.2906563752529825,"score_spread":0.2467494302362729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}