{"id":"W4206994211","doi":"10.3390/cells11030380","title":"From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Ubiquitin ligase; Ubiquitin; Proteostasis; Biology; Proteasome; Ubiquitin-Protein Ligases; Cell biology; Endoplasmic reticulum; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141645,0.0002250511,0.0005115815,0.00006600005,0.0000417739,0.00001038691,0.0001799368,0.0002201401,0.0002532393],"category_scores_gemma":[0.00004686003,0.0001959699,0.0001691437,0.0001007724,0.00002810106,0.000001210934,0.0003165347,0.0001535006,0.00002216977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552992,"about_ca_system_score_gemma":0.00006819996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001070004,"about_ca_topic_score_gemma":0.000001935078,"domain_scores_codex":[0.9987934,0.0001663742,0.0003035861,0.0004874643,0.00008302327,0.0001661683],"domain_scores_gemma":[0.9994038,0.00002714909,0.00012599,0.0002783957,0.00001419067,0.0001504286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002292165,0.0003806972,0.00004981429,0.004793456,0.0001664272,0.00006179341,0.0001192986,0.000008025224,0.388381,0.0001897104,0.0009773449,0.6046432],"study_design_scores_gemma":[0.0001433051,0.0002609701,0.00003061853,0.0003851212,0.00007275393,0.000001073913,0.00001081786,7.426492e-7,0.01101965,0.0001475493,0.9876996,0.000227795],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07350525,0.9249272,0.000001575871,0.000007329935,0.00011347,0.0005316603,0.0005353857,0.000006246265,0.0003718381],"genre_scores_gemma":[0.01656473,0.9814181,0.0000165375,0.0000815013,0.0003179243,0.0001663081,0.001184978,0.00002679382,0.0002231281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9867222,"threshold_uncertainty_score":0.7991421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390694501670963,"score_gpt":0.2906563752529825,"score_spread":0.2467494302362729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}