{"id":"W4206994761","doi":"10.1101/2022.01.18.476864","title":"Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sinai Health System; Health Sciences Centre; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital; National Research Council Canada; York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Cytokine; Immunology; CD8; Granzyme B; ELISPOT; T cell; Ex vivo; Biology; Cytotoxic T cell; Immunity; Immune system; Medicine; In vivo; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004201821,0.0002103551,0.0002580802,0.0001565913,0.0001934255,0.0002215173,0.00008366293,0.0002020913,0.001110836],"category_scores_gemma":[0.0003199394,0.00009422942,0.000208576,0.0001270513,0.0000938783,0.0001752716,0.0001404398,0.0003296913,0.0003542526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011156,"about_ca_system_score_gemma":0.000104696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007952626,"about_ca_topic_score_gemma":0.0008362987,"domain_scores_codex":[0.9999255,0.00001649619,0.000005229444,0.00002208837,0.00001148295,0.00001921752],"domain_scores_gemma":[0.9997678,0.00004262165,0.00007545864,0.00002126291,0.00004471834,0.00004817278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001704177,0.0004046679,0.7203639,0.00005977768,0.0000756314,0.0004502621,0.0004762676,0.0009241347,0.2612736,0.00005160156,0.0001711958,0.01404486],"study_design_scores_gemma":[0.00001764544,0.004815808,0.9711965,0.000008315781,0.00006804379,0.0006527275,0.0002722637,0.001622935,0.02076293,0.00004919015,0.0005223391,0.00001113847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993273,0.00006187224,0.0002752272,0.000006032855,0.000001244652,0.000008014238,0.0001687957,0.000005939545,0.0001457419],"genre_scores_gemma":[0.9991574,0.00003144875,0.0001135145,0.00001034857,0.00000172901,0.000009544337,0.0003815705,0.000001075592,0.0002933017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001110836,"threshold_uncertainty_score":0.003716052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08396389090439813,"score_gpt":0.327859051433015,"score_spread":0.2438951605286168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}