{"id":"W4206997442","doi":"10.1093/ecco-jcc/jjab232.729","title":"P603 INSPIRE: 6-month interim analysis from an observational post-marketing registry on the effectiveness and safety of darvadstrocel in patients with Crohn’s disease and complex perianal fistulas","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Diverticular Disease and Complications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Interim analysis; Adverse effect; Observational study; Cohort; Clinical trial; Interim; Crohn's disease; Surgery; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003231154,0.00009161319,0.0002792529,0.00009857603,0.0001733419,0.00003739359,0.00007328402,0.00001448823,0.0001056209],"category_scores_gemma":[0.0001183947,0.00006471142,0.00006396589,0.0001894205,0.0001075879,0.00007665168,0.00006521207,0.0001348403,4.303276e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005227837,"about_ca_system_score_gemma":0.0001073579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001438973,"about_ca_topic_score_gemma":0.00004339184,"domain_scores_codex":[0.9989175,0.000259295,0.0002778612,0.0001470386,0.0003096767,0.00008863111],"domain_scores_gemma":[0.9990497,0.0002202672,0.0002135229,0.0001477877,0.0002105413,0.000158231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02802139,0.0004796716,0.968484,0.00004876066,0.0004656466,0.000071442,0.0001650543,0.00007053687,0.00002788375,0.0004401902,0.00003442809,0.001691025],"study_design_scores_gemma":[0.001922781,0.0005051734,0.9955099,0.0001339011,0.0006350849,0.000007274172,0.0004859749,0.000447502,0.000002597083,0.0001380819,0.0001443777,0.0000673278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983814,0.0001866808,0.00002843742,0.0007459852,0.00001306131,0.0002017885,0.0003625671,0.00000203828,0.00007804597],"genre_scores_gemma":[0.9993253,0.00001765511,0.00006166586,0.000448019,0.00002210388,0.00001428151,0.00009790763,0.000006322365,0.000006770536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02702595,"threshold_uncertainty_score":0.2638855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063607328418886,"score_gpt":0.2649475164847761,"score_spread":0.2443114432005872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}