{"id":"W4206997442","doi":"10.1093/ecco-jcc/jjab232.729","title":"P603 INSPIRE: 6-month interim analysis from an observational post-marketing registry on the effectiveness and safety of darvadstrocel in patients with Crohn’s disease and complex perianal fistulas","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Diverticular Disease and Complications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Interim analysis; Adverse effect; Observational study; Cohort; Clinical trial; Interim; Crohn's disease; Surgery; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01445314,0.0007047743,0.001820506,0.0006657391,0.000548873,0.001700472,0.0007714554,0.001057592,0.005398304],"category_scores_gemma":[0.01816097,0.000489511,0.004007554,0.001017142,0.0005977161,0.001584027,0.0009602312,0.002246715,0.001167721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000779843,"about_ca_system_score_gemma":0.001277933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399476,"about_ca_topic_score_gemma":0.0005186368,"domain_scores_codex":[0.9896747,0.005117121,0.001012713,0.001365753,0.001998237,0.000831464],"domain_scores_gemma":[0.9742489,0.006985175,0.01211534,0.003464382,0.001847905,0.001338228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3620014,0.007122836,0.5265253,0.001682765,0.01210941,0.0007053454,0.0003618712,0.003164335,0.003224277,0.0009492248,0.01830589,0.06384738],"study_design_scores_gemma":[0.04262807,0.08002338,0.8434727,0.000307354,0.007960824,0.0011892,0.0002040893,0.006287269,0.004042202,0.001030708,0.01268216,0.000172072],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604761,0.001705992,0.003314736,0.0006669209,0.0001170768,0.002400373,0.0257816,0.0001724758,0.005364654],"genre_scores_gemma":[0.9677536,0.0003189941,0.002383367,0.0006306538,0.0002180945,0.003822434,0.02306631,0.00004908144,0.00175762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01445314,"threshold_uncertainty_score":0.07643646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063607328418886,"score_gpt":0.2649475164847761,"score_spread":0.2443114432005872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}