{"id":"W4206998102","doi":"10.1093/ecco-jcc/jjab232.077","title":"DOP38 Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Internal medicine; Gastroenterology; Placebo; Abdominal pain; Clinical trial; Randomized controlled trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003466424,0.000305586,0.0009798122,0.0001731534,0.0001067258,0.0002327623,0.0001446054,0.0002118874,0.002315135],"category_scores_gemma":[0.0005746317,0.0000886769,0.0003570561,0.0001308527,0.0001299632,0.0001910202,0.0001750934,0.000526385,0.0001999254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001652402,"about_ca_system_score_gemma":0.000355742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003274113,"about_ca_topic_score_gemma":0.001152556,"domain_scores_codex":[0.9998145,0.00006706228,0.00001548099,0.00002369017,0.00003119435,0.00004807292],"domain_scores_gemma":[0.9997868,0.00005927128,0.00006006903,0.00001103754,0.00001412104,0.00006878376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3269214,0.01165734,0.02351055,0.002041212,0.001098563,0.0002263995,0.0001065915,0.002581001,0.2554538,0.000243154,0.005369569,0.3707903],"study_design_scores_gemma":[0.06608573,0.3851777,0.4407853,0.0003552212,0.002050952,0.0009320095,0.0001582311,0.006751427,0.08775237,0.0003595494,0.009497927,0.00009352653],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995057,0.002718661,0.0002337232,0.00008627849,0.00003440727,0.00009663543,0.0004123609,0.00004755159,0.001313389],"genre_scores_gemma":[0.9981475,0.0005187494,0.0002053377,0.00005095724,0.00001969767,0.00005173221,0.0003369557,0.000002999594,0.0006659428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315135,"threshold_uncertainty_score":0.007744908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00709457924798893,"score_gpt":0.2498698784061163,"score_spread":0.2427752991581273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}