{"id":"W4206998699","doi":"10.3410/f.737434437.793581997","title":"Faculty Opinions recommendation of Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.","year":2021,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"University of California, San Francisco; Searle Scholars Program; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"G protein-coupled receptor; Allosteric regulation; Receptor; Agonist; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131739,0.001944418,0.00130906,0.004079383,0.0007179604,0.002292619,0.002079139,0.001958801,0.07270497],"category_scores_gemma":[0.009239615,0.0004545065,0.001200282,0.00595662,0.0003066971,0.001238948,0.001739573,0.001522495,0.07205803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001522367,"about_ca_system_score_gemma":0.00296241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01788833,"about_ca_topic_score_gemma":0.05488887,"domain_scores_codex":[0.9985188,0.0002583083,0.0001676029,0.0004752802,0.0004206575,0.0001593615],"domain_scores_gemma":[0.9955787,0.00144785,0.0005373763,0.000706622,0.001126534,0.0006028187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001488484,0.00003279004,0.002162936,0.002623424,0.00011079,0.00004336996,0.00003065277,0.0004015818,0.0006488198,0.0005363441,0.9848312,0.008429344],"study_design_scores_gemma":[0.0002468505,0.00002367371,0.004992236,0.000400058,0.00007570229,0.00004303993,0.00004588871,0.0006717307,0.001009232,0.0008078635,0.9916586,0.00002511273],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0002763234,0.0002197128,0.0001114893,0.000163087,0.0000354355,0.00001998672,0.9969584,0.0005691225,0.001646435],"genre_scores_gemma":[0.0006328212,0.0001583397,0.0004975603,0.00009085405,0.000009638174,0.00006788909,0.9976198,0.00007704928,0.0008459791],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.07270497,"threshold_uncertainty_score":0.2432224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107085501333206,"score_gpt":0.3085553484841743,"score_spread":0.2874844934708423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}