{"id":"W4207001169","doi":"10.1016/j.jaci.2021.10.038","title":"KVD900, an oral on-demand treatment for hereditary angioedema: Phase 1 study results","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Tolerability; Medicine; Hereditary angioedema; Pharmacokinetics; Pharmacodynamics; Crossover study; Coefficient of variation; Angioedema; Dosing; Bradykinin; Adverse effect; Placebo; Pharmacology; Internal medicine; Chemistry; Immunology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001044875,0.001057033,0.001291389,0.0002906936,0.0002544913,0.0009106254,0.0007251522,0.001084944,0.004088741],"category_scores_gemma":[0.000737593,0.0003075732,0.00122171,0.000257651,0.0004932437,0.0005807285,0.0001541774,0.002194031,0.0006417402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006400833,"about_ca_system_score_gemma":0.0009030281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002250214,"about_ca_topic_score_gemma":0.004428849,"domain_scores_codex":[0.9997112,0.0001285172,0.00001252362,0.0000424692,0.0000440265,0.00006125312],"domain_scores_gemma":[0.999525,0.000145741,0.00007690198,0.00003673534,0.00003085803,0.0001848738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.565,0.07541318,0.008095682,0.002265882,0.005194003,0.0004269938,0.0003761021,0.00263714,0.05565632,0.0007193197,0.0113759,0.2728395],"study_design_scores_gemma":[0.5924445,0.3633177,0.02772685,0.0001190863,0.002041627,0.0007277547,0.0001247191,0.00154168,0.004811605,0.0004055857,0.006681871,0.00005697308],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827875,0.007147244,0.0009973209,0.0006578499,0.0001764927,0.00139256,0.002453545,0.0001627302,0.004224862],"genre_scores_gemma":[0.9790978,0.00830775,0.001930614,0.001523108,0.0002437549,0.001005479,0.003728653,0.00007054348,0.004092267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004088741,"threshold_uncertainty_score":0.01367813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07856487498742455,"score_gpt":0.4034388701227199,"score_spread":0.3248739951352954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}