{"id":"W4207015623","doi":"10.1089/nat.2021.29004.ots","title":"17th Annual Meeting of the Oligonucleotide Therapeutics Society: A Tribute to Bob Letsinger, Progress in <i>N</i>  = 1 Treatments, and Successful First In-Humans CRISPR Trials","year":2022,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; McGill University","funders":"","keywords":"Tribute; Library science; Medicine; History; Art history; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008700144,0.0002600265,0.000410317,0.00006868633,0.0001949107,0.00003075226,0.0003883392,0.0001153135,0.000009636175],"category_scores_gemma":[0.00002279392,0.0002192451,0.0001881567,0.0003482505,0.0001116794,0.000006867996,0.0003698705,0.0002296903,4.670384e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006659308,"about_ca_system_score_gemma":0.00006584813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004516881,"about_ca_topic_score_gemma":0.0002053816,"domain_scores_codex":[0.9981588,0.0002272043,0.0005583123,0.0003949347,0.0002634567,0.0003973419],"domain_scores_gemma":[0.9992291,0.000057931,0.0001752598,0.0004344335,0.00004867147,0.0000546337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008239772,0.001122408,0.3053279,0.00018673,0.001013336,0.00001313372,0.01592728,0.005133922,0.6278862,0.0000915386,0.001272516,0.04120105],"study_design_scores_gemma":[0.009454192,0.002027829,0.1146192,0.000213469,0.0006005812,0.00004121033,0.0104085,0.002528462,0.520784,0.0002701635,0.3376221,0.001430266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876786,0.008680318,0.0002331029,0.002308318,0.0002044491,0.0006733956,0.0001410517,0.00001527601,0.00006550667],"genre_scores_gemma":[0.9970232,0.0008808392,0.0006730311,0.001108065,0.00007897554,0.00009476495,0.00001861104,0.00005348076,0.00006901641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3363496,"threshold_uncertainty_score":0.8940554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728894334026683,"score_gpt":0.3120626520839123,"score_spread":0.2947737087436455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}