{"id":"W4207015623","doi":"10.1089/nat.2021.29004.ots","title":"17th Annual Meeting of the Oligonucleotide Therapeutics Society: A Tribute to Bob Letsinger, Progress in <i>N</i>  = 1 Treatments, and Successful First In-Humans CRISPR Trials","year":2022,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; McGill University","funders":"","keywords":"Tribute; Library science; Medicine; History; Art history; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003912452,0.001640698,0.001296265,0.001008205,0.002873756,0.005579566,0.001218662,0.009394197,0.03178946],"category_scores_gemma":[0.006366776,0.0005297859,0.0009226996,0.000409433,0.001879367,0.002468769,0.002268852,0.01506974,0.02508828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002304558,"about_ca_system_score_gemma":0.004007268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004701854,"about_ca_topic_score_gemma":0.01488683,"domain_scores_codex":[0.9978657,0.000323052,0.0001080752,0.0003294673,0.001034119,0.0003395717],"domain_scores_gemma":[0.9962434,0.0005774968,0.0002042665,0.0001270363,0.00108483,0.001762962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004780904,0.00002537802,0.00009023379,0.00003859392,0.000007093836,0.00004000599,0.00002272729,0.00002664252,0.0003091263,0.0007429373,0.9868304,0.01181917],"study_design_scores_gemma":[0.0000132611,0.00002860687,0.0003990894,0.00008353,0.000005744084,0.00004330488,0.00007413586,0.00004685023,0.0001802262,0.00079195,0.998321,0.00001237364],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007763931,0.03577737,0.001168242,0.5074045,0.4324187,0.00008129685,0.000329084,0.0002260098,0.02181851],"genre_scores_gemma":[0.007739077,0.02449438,0.001786018,0.3037857,0.1561693,0.0002319823,0.0005420009,0.0003562711,0.5048953],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03178946,"threshold_uncertainty_score":0.1063463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728894334026683,"score_gpt":0.3120626520839123,"score_spread":0.2947737087436455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}