{"id":"W4207033793","doi":"10.1093/ecco-jcc/jjab232.699","title":"P573 The safety profile of upadacitinib maintenance therapy in ulcerative colitis in the Phase 3 U-ACHIEVE study is consistent with that in approved indications","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Adverse effect; Discontinuation; Ulcerative colitis; Context (archaeology); Internal medicine; Placebo; Rheumatoid arthritis; Psoriatic arthritis; Ankylosing spondylitis; Maintenance therapy; Janus kinase inhibitor; Gastroenterology; Surgery; Tofacitinib; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003611228,0.0001994853,0.0007906611,0.0002489765,0.000253685,0.001036332,0.0003131569,0.0003060773,0.003756142],"category_scores_gemma":[0.003590833,0.0001372279,0.0008600885,0.0005785387,0.0002856857,0.0004773007,0.000325905,0.0008560769,0.0006294555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004476953,"about_ca_system_score_gemma":0.001073771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004009372,"about_ca_topic_score_gemma":0.001379972,"domain_scores_codex":[0.9981672,0.0007525329,0.0001697085,0.0002075533,0.0005595176,0.0001436104],"domain_scores_gemma":[0.9976356,0.0007970187,0.0009105208,0.000250446,0.0002564551,0.0001500547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1771365,0.00388913,0.1826362,0.004259903,0.006870908,0.001357695,0.0003799576,0.003761484,0.07241561,0.001429716,0.02378243,0.5220805],"study_design_scores_gemma":[0.05166692,0.1240832,0.6497734,0.0009056702,0.005521906,0.008211938,0.0004724765,0.008007308,0.05660444,0.001597932,0.09304358,0.000111168],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636088,0.01025575,0.002473393,0.0006001149,0.00007457256,0.001034864,0.005461839,0.0002153394,0.01627545],"genre_scores_gemma":[0.9910123,0.001312578,0.001205304,0.0003889721,0.0000504671,0.0003492512,0.003797469,0.0000313456,0.001852314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003756142,"threshold_uncertainty_score":0.01909822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06037109507946218,"score_gpt":0.3631042763244964,"score_spread":0.3027331812450342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}