{"id":"W4207038717","doi":"10.1016/j.vph.2022.106953","title":"Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients","year":2022,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic; University of Alberta","funders":"Narodowa Agencja Wymiany Akademickiej; ME Research UK; Fundação para a Ciência e a Tecnologia; Chicken Farmers of Saskatchewan","keywords":"Enos; Nitric oxide; Internal medicine; Endocrinology; Endothelial dysfunction; Umbilical vein; Chemistry; Bradykinin; Receptor; Agonist; Medicine; Endothelium; In vitro; Nitric oxide synthase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003578666,0.000171076,0.0003405588,0.0003190717,0.0001249701,0.000007250945,0.0002014384,0.00006890544,0.007811103],"category_scores_gemma":[0.00008749806,0.0001757672,0.0001337869,0.0004316138,0.00004694987,0.00004857049,0.0002011615,0.0004680695,0.0005407726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005492982,"about_ca_system_score_gemma":0.0003291902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002605138,"about_ca_topic_score_gemma":0.000004065613,"domain_scores_codex":[0.9976103,0.0004457595,0.000299699,0.0005439831,0.0006044623,0.0004957995],"domain_scores_gemma":[0.999238,0.00007554763,0.00004937511,0.0002868847,0.0001004995,0.0002496581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001295259,0.001289906,0.005607194,0.0001803392,0.0002498162,0.0001654903,0.0006251357,0.0005173733,0.9675501,0.000002155222,0.02127407,0.001243173],"study_design_scores_gemma":[0.02521056,0.002864823,0.02302769,0.00007822265,0.0002638747,0.0000329588,0.0002734897,0.002241273,0.8897498,0.00002747987,0.05576063,0.0004691449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958613,0.0001096397,0.000008569369,0.0005497593,0.001742625,0.00140413,0.00006554811,0.00005214327,0.0002062923],"genre_scores_gemma":[0.9977888,0.00004636278,0.0003626882,0.000182126,0.0001812336,0.0004983419,0.0002163761,0.00004180612,0.0006822399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07780024,"threshold_uncertainty_score":0.9930959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667745078965971,"score_gpt":0.2797890589882649,"score_spread":0.2631116081986052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}