{"id":"W4207038717","doi":"10.1016/j.vph.2022.106953","title":"Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients","year":2022,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic; University of Alberta","funders":"Narodowa Agencja Wymiany Akademickiej; ME Research UK; Fundação para a Ciência e a Tecnologia; Chicken Farmers of Saskatchewan","keywords":"Enos; Nitric oxide; Internal medicine; Endocrinology; Endothelial dysfunction; Umbilical vein; Chemistry; Bradykinin; Receptor; Agonist; Medicine; Endothelium; In vitro; Nitric oxide synthase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771955,0.0002049072,0.0004192882,0.0001945855,0.0002065914,0.000305365,0.0001044495,0.0003348553,0.001338796],"category_scores_gemma":[0.000359826,0.0001149875,0.0002282798,0.0001325759,0.0001446195,0.0001569138,0.000169494,0.0004405735,0.0002028169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000895071,"about_ca_system_score_gemma":0.00008090473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000423387,"about_ca_topic_score_gemma":0.0003880611,"domain_scores_codex":[0.9997672,0.00005506273,0.00002293573,0.00006820889,0.00004313379,0.00004351743],"domain_scores_gemma":[0.9998673,0.00002433471,0.00003402305,0.00001315418,0.00003047649,0.00003070612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003006906,0.0001536255,0.009641898,0.0001661682,0.00004695002,0.0006246552,0.0002377831,0.00004506166,0.9821128,0.00003640438,0.0001975886,0.003730168],"study_design_scores_gemma":[0.000295112,0.006545398,0.496204,0.0001096948,0.0002885031,0.005268592,0.001366269,0.001937389,0.4818737,0.0002538579,0.005802894,0.0000545511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964845,0.002208417,0.0003795306,0.00008675765,0.00006489802,0.00001236592,0.0002611144,0.000008131481,0.0004942696],"genre_scores_gemma":[0.9974367,0.0008280923,0.0004148395,0.0001401433,0.00004815483,0.00003213112,0.0004871041,0.000002706573,0.0006102102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338796,"threshold_uncertainty_score":0.004478753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667745078965971,"score_gpt":0.2797890589882649,"score_spread":0.2631116081986052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}