{"id":"W4207039879","doi":"10.1136/jitc-2021-004310","title":"Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; ECOG-ACRIN Cancer Research Group; University of Pittsburgh; American College of Radiology Imaging Network; Canadian Cancer Society Research Institute; Moffitt Cancer Center; Bristol-Myers Squibb","keywords":"Medicine; Ipilimumab; Internal medicine; Oncology; Melanoma; Proportional hazards model; Adjuvant; Immune system; Population; Primary tumor; Immunotherapy; Hazard ratio; FOXP3; Immunology; Gastroenterology; Metastasis; Cancer; Cancer research; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413506,0.0001497967,0.0002729516,0.0002453597,0.0001965959,0.0003728239,0.000113667,0.0002009547,0.001500422],"category_scores_gemma":[0.0008469933,0.00009289597,0.000153042,0.0002170377,0.0001592289,0.0002247294,0.0001930704,0.0002995355,0.0002377656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001672298,"about_ca_system_score_gemma":0.0001212491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002826362,"about_ca_topic_score_gemma":0.0003434134,"domain_scores_codex":[0.999893,0.00002613535,0.000006875128,0.00003065707,0.00001741254,0.00002594441],"domain_scores_gemma":[0.9994082,0.0001039183,0.0002575545,0.00003857209,0.00004285679,0.0001488032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001108419,0.00005844259,0.9921834,0.00001369374,0.00002802459,0.0002112836,0.00004129839,0.00005569881,0.003012342,0.00001383154,0.00006768599,0.003205907],"study_design_scores_gemma":[0.00002367014,0.0004436231,0.9972882,0.000003465696,0.00003626967,0.001130123,0.00006581584,0.0002948924,0.0005271801,0.00003215712,0.0001522025,0.000002347675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996554,0.0001133465,0.00003300272,0.00001173329,0.000001869583,0.000001880694,0.00003901095,0.000001564697,0.0001422117],"genre_scores_gemma":[0.9998295,0.00002787702,0.00001936687,0.000006989362,0.000005060097,0.000001499701,0.00005386668,4.916615e-7,0.000055448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500422,"threshold_uncertainty_score":0.005019426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008562596039694056,"score_gpt":0.2555783190003248,"score_spread":0.2470157229606308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}