{"id":"W4207043612","doi":"10.29173/eureka28752","title":"Smart Oncolytic Adenovirotherapy to Induce Killing of Cancer Cells and Elicit Antitumor Immunity","year":2022,"lang":"en","type":"article","venue":"Eureka","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oncolytic virus; Virotherapy; Immune system; Cancer; Immunology; Cancer cell; Immunity; Immunosuppression; Immunogenic cell death; Biology; Cancer research; Immunotherapy; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876083,0.0001066567,0.0001365963,0.00007076316,0.0001434757,0.00001099392,0.000250383,0.00003913937,0.000233559],"category_scores_gemma":[0.00001054183,0.0001126324,0.00004341636,0.000184317,0.00004881909,0.000001922945,0.000214708,0.0001523083,0.000003170761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002942958,"about_ca_system_score_gemma":0.0001351994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003992727,"about_ca_topic_score_gemma":0.0002827838,"domain_scores_codex":[0.9990515,0.000144377,0.0001483611,0.0002408315,0.0002021398,0.0002127542],"domain_scores_gemma":[0.9994859,0.00001401118,0.00005179319,0.0003180178,0.00004910542,0.00008116223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007123075,0.00006920697,0.001731459,0.00001112629,0.00004593776,0.000002785606,0.0001604588,0.0001790013,0.9888523,0.000005323619,0.0007958222,0.007434328],"study_design_scores_gemma":[0.000469585,0.001929917,0.001063065,0.000007671812,0.000006353298,0.000003039494,0.0001029366,0.0000375988,0.9560505,0.00001745657,0.04017682,0.0001350392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955823,0.003470073,0.00008844425,0.0002811805,0.000101021,0.0002162887,0.00006770686,0.000006646353,0.0001863534],"genre_scores_gemma":[0.9971978,0.0008483416,0.0001001155,0.0009770162,0.00008982016,0.00007669285,0.00001484794,0.0000296603,0.000665719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03938099,"threshold_uncertainty_score":0.4593014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088053241880734,"score_gpt":0.3171552356191955,"score_spread":0.2962747032003882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}