{"id":"W4207043612","doi":"10.29173/eureka28752","title":"Smart Oncolytic Adenovirotherapy to Induce Killing of Cancer Cells and Elicit Antitumor Immunity","year":2022,"lang":"en","type":"article","venue":"Eureka","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oncolytic virus; Virotherapy; Immune system; Cancer; Immunology; Cancer cell; Immunity; Immunosuppression; Immunogenic cell death; Biology; Cancer research; Immunotherapy; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181623,0.0003015769,0.0003355274,0.0004863733,0.0001196676,0.0004958005,0.0002176228,0.0004141258,0.002116197],"category_scores_gemma":[0.0001267631,0.0001303203,0.0004462311,0.0002686114,0.0001738804,0.0004469706,0.0002893437,0.0009804673,0.0006642207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004373995,"about_ca_system_score_gemma":0.0002907973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003848679,"about_ca_topic_score_gemma":0.000641861,"domain_scores_codex":[0.9999098,0.00001423663,0.000009327718,0.00001595849,0.00003419619,0.0000164945],"domain_scores_gemma":[0.9999726,0.000007225147,0.000005817851,0.000002441616,0.000007735176,0.000004112519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002649558,0.0002311144,0.0005425776,0.007703498,0.0001000104,0.0004496533,0.0002255747,0.001510113,0.5746456,0.02031714,0.0110408,0.3829689],"study_design_scores_gemma":[0.00007642521,0.0009331359,0.001888083,0.0007254878,0.0001391981,0.001750781,0.00008116063,0.001637027,0.3109107,0.00263721,0.6791763,0.00004457155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.06140702,0.8672861,0.02464685,0.001771916,0.001673778,0.0002674452,0.0008657807,0.0005537589,0.04152724],"genre_scores_gemma":[0.321088,0.6275747,0.01535536,0.001598062,0.0003518637,0.0002776273,0.001433775,0.00007622043,0.03224437],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002116197,"threshold_uncertainty_score":0.007079422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088053241880734,"score_gpt":0.3171552356191955,"score_spread":0.2962747032003882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}