{"id":"W4207043759","doi":"10.3389/fnana.2021.784478","title":"Type II Opsins in the Eye, the Pineal Complex and the Skin of Xenopus laevis: Using Changes in Skin Pigmentation as a Readout of Visual and Circadian Activity","year":2022,"lang":"en","type":"review","venue":"Frontiers in Neuroanatomy","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chromatophore; Xenopus; Opsin; Biology; Melatonin; Melanophore; Circadian rhythm; Photosensitivity; Adaptation (eye); Skin color; Cell biology; Neuroscience; Genetics; Gene; Rhodopsin; Retinal; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009924523,0.0003119294,0.001023829,0.0005421903,0.0001881337,0.00004647634,0.0004804036,0.0001224427,0.00001749193],"category_scores_gemma":[0.0003589183,0.0001966005,0.0001051302,0.001553121,0.0006441324,0.0001146687,0.0002579337,0.0007806647,3.185277e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173378,"about_ca_system_score_gemma":0.0002081776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004501443,"about_ca_topic_score_gemma":0.0001748187,"domain_scores_codex":[0.9962741,0.001978928,0.0005100202,0.0005199633,0.0003892363,0.0003278087],"domain_scores_gemma":[0.9983989,0.000652145,0.0005020094,0.0003891244,0.00001332112,0.00004448531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003887868,0.0005004284,0.00242143,0.004422745,0.00006346044,0.0002462886,0.01635412,0.00003054881,0.0002970597,0.005049041,0.0003551841,0.9698709],"study_design_scores_gemma":[0.005725397,0.0006862629,0.01627647,0.003228338,0.0006067841,0.0006040026,0.004171142,0.006134931,0.001039792,0.000488675,0.9599388,0.001099399],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3214285,0.6730179,0.000009948259,0.0004721485,0.000779496,0.003265451,0.00008898855,0.00001257365,0.0009249547],"genre_scores_gemma":[0.2756093,0.7238334,0.00002610403,0.0003103582,0.00004792996,0.00009550171,0.000008589577,0.00003951844,0.0000293225],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9687715,"threshold_uncertainty_score":0.8017136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05711138919109466,"score_gpt":0.3436216801321471,"score_spread":0.2865102909410524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}