{"id":"W4207053520","doi":"","title":"Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans","year":2022,"lang":"en","type":"article","venue":"DOAJ (DOAJ: Directory of Open Access Journals)","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Vaccination; Immunology; Immunogenicity; Bronchoalveolar lavage; Nebulizer; Immunity; Adverse effect; Immune system; Respiratory tract; Aerosol; Respiratory system; Tuberculosis vaccines; Inhalation; Tuberculosis; Lung; Pharmacology; Internal medicine; Pathology; Mycobacterium tuberculosis; Anesthesia; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002436973,0.0004011231,0.001076354,0.001843065,0.0009491026,0.0001949771,0.002790949,0.0002596445,0.01929339],"category_scores_gemma":[0.000532143,0.0004088719,0.0003412071,0.001812668,0.0001409522,0.001167388,0.002004368,0.001468175,0.00002180449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232166,"about_ca_system_score_gemma":0.0003920456,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009706992,"about_ca_topic_score_gemma":0.0005089379,"domain_scores_codex":[0.9948584,0.002232153,0.001569799,0.0005070781,0.0002865381,0.0005460494],"domain_scores_gemma":[0.9970068,0.0005818008,0.001111733,0.0007748207,0.000458945,0.00006585236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001626182,0.0008869261,0.1079648,0.0000512022,0.0005641831,0.0000168831,0.0006084811,0.0003562394,0.8787772,0.000091913,0.005771535,0.003284382],"study_design_scores_gemma":[0.002052695,0.0001277247,0.6537852,0.0000932234,0.0001234967,0.00004183719,0.0007747869,0.000004443675,0.337919,0.0001879504,0.004500755,0.0003888831],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688226,0.02881023,0.00002654602,0.0001573284,0.0009529036,0.0006670997,0.0002305771,0.00003994315,0.0002927737],"genre_scores_gemma":[0.9965172,0.002618534,0.0000175022,0.000249997,0.00004570259,0.0001521547,0.00008287818,0.00005614495,0.0002598318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5458204,"threshold_uncertainty_score":0.9998363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1255675699896808,"score_gpt":0.4565157638431262,"score_spread":0.3309481938534454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}