{"id":"W4207054094","doi":"10.3390/toxins14020079","title":"Chemical Synthesis of a Functional Fluorescent-Tagged α-Bungarotoxin","year":2022,"lang":"en","type":"article","venue":"Toxins","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; Université de Montréal; Montreal Heart Institute","funders":"Association Nationale de la Recherche et de la Technologie; Federación Española de Enfermedades Raras; Fondation Leducq; Conseil Régional des Pays de la Loire; Agence Nationale de la Recherche","keywords":"Bungarotoxin; Fluorescence; Peptide; Biochemistry; Fluorophore; Nicotinic agonist; Chemistry; Acetylcholine receptor; Snake venom; Venom; Biophysics; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009828709,0.00007065607,0.0001041351,0.00002503405,0.00010666,0.000003178767,0.00009799244,0.00002852146,0.0004031875],"category_scores_gemma":[0.00006867332,0.0000722856,0.00008444922,0.00005794072,0.00004432134,9.633308e-7,0.0001665259,0.00005825069,0.000008149769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001716251,"about_ca_system_score_gemma":0.00003660556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008881301,"about_ca_topic_score_gemma":0.000004966967,"domain_scores_codex":[0.9994226,0.0000380351,0.0001362168,0.0001541844,0.000139699,0.0001093367],"domain_scores_gemma":[0.9997433,0.00001052721,0.00005379999,0.0001336936,0.00002744021,0.00003122545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144123,0.0001494045,0.0004911804,0.000009564716,0.00004915478,0.000001125834,0.00004783938,0.00008069914,0.9919976,0.0005133201,0.005795009,0.0007507004],"study_design_scores_gemma":[0.0004717444,0.0002261978,0.007944394,0.000004235852,0.00002389915,0.00002481478,0.0003710323,0.0001504664,0.938593,0.00004010124,0.05196347,0.0001866311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951942,0.0002181583,0.0001653844,0.000222414,0.00007871367,0.0001118001,0.00006658724,0.00001268768,0.003930071],"genre_scores_gemma":[0.99884,0.00001330118,0.0001774139,0.0001485918,0.00007481316,0.00008450128,0.00004176035,0.000009909535,0.0006096561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05340457,"threshold_uncertainty_score":0.441462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184203040517594,"score_gpt":0.2157349433202855,"score_spread":0.2038929129151095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}