{"id":"W4207056005","doi":"10.1093/ecco-jcc/jjab232.448","title":"P321 Mucosal Healing and Clinical remission after Treatment with Adalimumab in Small Intestinal Crohn’s Disease (SIMCHA study): final results from a prospective, open-label, single-arm study","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Adalimumab; Internal medicine; Gastroenterology; Capsule endoscopy; Crohn's disease; Calprotectin; Infliximab; Prospective cohort study; Inflammatory bowel disease; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005411572,0.001225359,0.001846292,0.0004611113,0.0004838798,0.001124708,0.0006611547,0.001214456,0.002282544],"category_scores_gemma":[0.002696992,0.000591553,0.001734567,0.0005957837,0.0009189564,0.0009656317,0.000583823,0.001260593,0.0005508778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003483641,"about_ca_system_score_gemma":0.0006636457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003908812,"about_ca_topic_score_gemma":0.0006397399,"domain_scores_codex":[0.9982896,0.001128472,0.0001164508,0.0001711794,0.0001788022,0.0001154964],"domain_scores_gemma":[0.9972138,0.0006991263,0.0008890467,0.0002703363,0.0002325589,0.0006951698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8177078,0.01366345,0.1255739,0.001056902,0.004633299,0.0002666635,0.0002738425,0.0003623769,0.006725689,0.00007960042,0.0008965243,0.02875986],"study_design_scores_gemma":[0.3091579,0.285789,0.3963462,0.000143987,0.003702205,0.0004453705,0.0001721786,0.0009703862,0.00125724,0.0001487436,0.001791563,0.00007519191],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957085,0.002356507,0.0002201189,0.00009140784,0.00004368006,0.000547437,0.0004448537,0.00001681665,0.0005706677],"genre_scores_gemma":[0.9967346,0.0007151788,0.0004028323,0.0001671247,0.0001665268,0.000588013,0.000693989,0.000005822286,0.0005258826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005411572,"threshold_uncertainty_score":0.02861941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795666701314746,"score_gpt":0.3108025991274596,"score_spread":0.2728459321143121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}