{"id":"W4207057649","doi":"10.1016/j.ymthe.2022.01.033","title":"A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Uniwersytet Jagielloński w Krakowie; Sichuan University; China Postdoctoral Science Foundation; Ministry of Science and Technology of the People's Republic of China; City of Hope; National Natural Science Foundation of China; European Regional Development Fund; Fundacja na rzecz Nauki Polskiej; European Commission; Canadian Institute for Theoretical Astrophysics; Meso Scale Diagnostics; Merck; National Cancer Institute; West China Hospital, Sichuan University; AbbVie; Roche; Narodowym Centrum Nauki; Narodowe Centrum Nauki; National Institute for Health and Care Research; Novartis; Pfizer","keywords":"microRNA; Pancreatitis; Acute pancreatitis; Cancer research; Biology; Cell biology; Medicine; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005915307,0.0005341292,0.0005948421,0.0004245325,0.0005470844,0.00141122,0.000389792,0.00108051,0.003091766],"category_scores_gemma":[0.0007210617,0.0002455694,0.0004686441,0.0001668991,0.0006033628,0.0008542886,0.001010096,0.001530268,0.0007550134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007302079,"about_ca_system_score_gemma":0.0006366695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001544933,"about_ca_topic_score_gemma":0.000294601,"domain_scores_codex":[0.9996418,0.00007848357,0.0000310467,0.00005956213,0.00009143636,0.0000976443],"domain_scores_gemma":[0.9998106,0.00003214911,0.00004906092,0.00001753517,0.00004080564,0.00004981132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003378768,0.0004302693,0.003258314,0.001005338,0.0001480088,0.001887989,0.0002877765,0.0006605787,0.8291256,0.02000683,0.01166992,0.1281407],"study_design_scores_gemma":[0.001169232,0.004248972,0.02801068,0.0006318467,0.000356494,0.005099868,0.0008879505,0.004584278,0.7152566,0.01927627,0.2203351,0.0001425827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6983361,0.1819002,0.03395041,0.02616157,0.007419526,0.0004712559,0.0007429949,0.00210982,0.04890806],"genre_scores_gemma":[0.9673079,0.01480708,0.006406728,0.002590768,0.0007338359,0.0002353785,0.0002542064,0.0001081584,0.007556076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003091766,"threshold_uncertainty_score":0.01034296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252917649780529,"score_gpt":0.2686617361753932,"score_spread":0.2561325596775879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}