{"id":"W4207057649","doi":"10.1016/j.ymthe.2022.01.033","title":"A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Uniwersytet Jagielloński w Krakowie; Sichuan University; China Postdoctoral Science Foundation; Ministry of Science and Technology of the People's Republic of China; City of Hope; National Natural Science Foundation of China; European Regional Development Fund; Fundacja na rzecz Nauki Polskiej; European Commission; Canadian Institute for Theoretical Astrophysics; Meso Scale Diagnostics; Merck; National Cancer Institute; West China Hospital, Sichuan University; AbbVie; Roche; Narodowym Centrum Nauki; Narodowe Centrum Nauki; National Institute for Health and Care Research; Novartis; Pfizer","keywords":"microRNA; Pancreatitis; Acute pancreatitis; Cancer research; Biology; Cell biology; Medicine; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443073,0.0001184646,0.0002592023,0.00005232346,0.00009853897,0.000006433924,0.00003862811,0.0000403901,0.0001279954],"category_scores_gemma":[0.000007659397,0.0001123045,0.00008505295,0.00007474084,0.00003151643,0.00002113706,0.00002526861,0.0001027009,0.000001994088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070896,"about_ca_system_score_gemma":0.00004202793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001672295,"about_ca_topic_score_gemma":0.00001320768,"domain_scores_codex":[0.9992631,0.00006803069,0.0001488899,0.0002390356,0.00009247041,0.0001884578],"domain_scores_gemma":[0.9997082,0.00002947025,0.00004158637,0.0001561693,0.00001572452,0.0000488699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001022855,0.0003135178,0.02659689,0.00001704366,0.0004424875,0.002978978,0.0009385758,0.00001420933,0.9566495,0.0006536503,0.00005797377,0.01031434],"study_design_scores_gemma":[0.0324114,0.005786732,0.09905215,0.00009517877,0.0004210464,0.003432856,0.0004467945,0.0002481933,0.8359771,0.003678223,0.0178559,0.0005944608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895361,0.008141872,0.0005634168,0.000570968,0.00004427729,0.000646034,0.00005050598,0.00002467818,0.0004221141],"genre_scores_gemma":[0.9939729,0.0008425568,0.002737847,0.001563725,0.00001460577,0.0005206643,0.00007418106,0.00002223042,0.0002513168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1206724,"threshold_uncertainty_score":0.4579644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252917649780529,"score_gpt":0.2686617361753932,"score_spread":0.2561325596775879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}