{"id":"W4207059954","doi":"10.3390/cancers14030539","title":"Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"Fondazione Italiana per la Ricerca sul Cancro; Università della Calabria; Associazione Italiana per la Ricerca sul Cancro","keywords":"Tumor microenvironment; Cellular adaptation; Hypoxia (environmental); Tumor progression; Hormone; Signal transduction; Biology; Immune system; Cell signaling; Cancer research; Cancer cell; Tumor hypoxia; Receptor; Cell biology; Cancer; Immunology; Chemistry; Medicine; Internal medicine; Endocrinology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328972,0.0007103874,0.001014107,0.001572416,0.0002807723,0.000863619,0.0005845808,0.0008760948,0.002052538],"category_scores_gemma":[0.0003710521,0.0002299967,0.0003473526,0.001555526,0.0004052826,0.001133253,0.0005695511,0.001574969,0.001070088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006645151,"about_ca_system_score_gemma":0.0009274684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008822881,"about_ca_topic_score_gemma":0.001603288,"domain_scores_codex":[0.9998957,0.00001920017,0.00001406998,0.00001977786,0.00003785675,0.00001331812],"domain_scores_gemma":[0.9998682,0.00006553405,0.00001522446,0.000004056074,0.00003106902,0.00001587399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008072449,0.00006307374,0.0002434887,0.01504893,0.00007956086,0.0004024722,0.0001052052,0.0005566477,0.003986297,0.008194584,0.03403839,0.9372006],"study_design_scores_gemma":[0.000008052266,0.00006368758,0.0007133789,0.001924388,0.00006117285,0.001519665,0.00005421093,0.00008246888,0.000590198,0.002423295,0.9925454,0.00001412408],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001300668,0.9982697,0.0001446278,0.0003139974,0.0001909333,0.000002695199,0.00001452963,0.000006815892,0.0009265472],"genre_scores_gemma":[0.000569835,0.9985098,0.0001440336,0.0001470225,0.000141491,0.000004279783,0.00002164449,0.000001239435,0.0004605186],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002052538,"threshold_uncertainty_score":0.006866455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447610242233422,"score_gpt":0.288181588428041,"score_spread":0.2637054860057068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}