{"id":"W4207062759","doi":"10.1093/ecco-jcc/jjab232.080","title":"DOP41 Efficacy and safety of extended induction treatment with upadacitinib 45 mg once daily followed by maintenance upadacitinib 15 or 30 mg once daily in patients with moderately to severely active Ulcerative Colitis","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Maintenance therapy; Ulcerative colitis; Clinical endpoint; Internal medicine; Gastroenterology; Loading dose; Induction chemotherapy; Clinical trial; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005688041,0.0002750566,0.001185848,0.0001861185,0.0002215568,0.0005215063,0.0001894405,0.0003297095,0.001541825],"category_scores_gemma":[0.0007452196,0.0001655902,0.001014394,0.0002432317,0.0002614507,0.0003367922,0.0002789675,0.0007143019,0.0002142846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004408747,"about_ca_system_score_gemma":0.0005083929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003881125,"about_ca_topic_score_gemma":0.0008945186,"domain_scores_codex":[0.9996502,0.0001342372,0.00003598586,0.00006474063,0.00005502605,0.00005973466],"domain_scores_gemma":[0.9995889,0.0001006053,0.0001174184,0.00003608654,0.00002695369,0.0001300532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6281696,0.007593965,0.06381021,0.0010521,0.00226929,0.0004007371,0.0002257896,0.002931621,0.04446388,0.000162565,0.001365376,0.2475549],"study_design_scores_gemma":[0.1246465,0.5122447,0.3380777,0.0002939773,0.002590919,0.001143097,0.0002465435,0.004207449,0.01008764,0.0002773373,0.006100339,0.00008382864],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969293,0.001864302,0.00009525928,0.00004702199,0.00001703263,0.00009397572,0.0001658886,0.00001068949,0.000776638],"genre_scores_gemma":[0.999022,0.0002759127,0.0001422452,0.00004457585,0.00001623441,0.0000458382,0.0002319384,0.000001284678,0.0002199191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541825,"threshold_uncertainty_score":0.005157888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007531866534635997,"score_gpt":0.2338493363705179,"score_spread":0.2263174698358819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}