{"id":"W4207064406","doi":"10.1093/ecco-jcc/jjab232.436","title":"P309 Withdrawal of thiopurines in Inflammatory Bowel Disease patients in stable remission: a prospective, multicentre cohort study","year":2022,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Thiopurine methyltransferase; Internal medicine; Azathioprine; Discontinuation; Ulcerative colitis; Inflammatory bowel disease; Gastroenterology; Mercaptopurine; Concomitant; Crohn's disease; Prospective cohort study; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008605115,0.0003730567,0.0006924312,0.0006176873,0.000631485,0.0007673703,0.0005080829,0.0005961919,0.001758773],"category_scores_gemma":[0.001993763,0.0004087651,0.0008651551,0.001226835,0.0002864818,0.0005912635,0.0004526571,0.0006592165,0.0003468918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829401,"about_ca_system_score_gemma":0.0003284477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004183527,"about_ca_topic_score_gemma":0.003071575,"domain_scores_codex":[0.9992624,0.0002281615,0.00007123297,0.000206959,0.0001065673,0.0001246065],"domain_scores_gemma":[0.9982981,0.0002930352,0.0007809526,0.0001688924,0.0001385491,0.0003205582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008684221,0.00007648374,0.9977788,0.00001097285,0.0001143279,0.0001892007,0.00006542912,0.0000190492,0.0001780849,0.000006243567,0.00006932971,0.0006236518],"study_design_scores_gemma":[0.00007229798,0.0003905297,0.9987091,0.000005149762,0.00008058519,0.0003527236,0.0001012888,0.0001308937,0.00002756957,0.000009753296,0.000114935,0.000005120672],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995129,0.0001496927,0.00003363418,0.00001260854,0.000003323052,0.000009773031,0.0001921226,0.000001054774,0.00008488694],"genre_scores_gemma":[0.9994542,0.00007144042,0.00002567809,0.0000141852,0.000009810256,0.00001182237,0.0003320621,0.000001387108,0.00007930565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004183527,"threshold_uncertainty_score":0.008318365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003016567818548557,"score_gpt":0.2162473435798527,"score_spread":0.2132307757613041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}