{"id":"W4207067408","doi":"10.1007/s00204-021-03217-7","title":"Hepatic metabolism of chlorinated derivatives of bisphenol A (ClxBPA) and interspecies differences between rats and humans","year":2022,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail","keywords":"Chemistry; Bisphenol A; Physiologically based pharmacokinetic modelling; Toxicokinetics; Metabolism; Metabolite; Drug metabolism; Glutathione; Pharmacology; Hepatocyte; Oxidative phosphorylation; Biochemistry; Pharmacokinetics; In vitro; Biology; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299545,0.0002200429,0.0001586668,0.000616131,0.0002192053,0.0002889371,0.00007734654,0.0002216424,0.001438801],"category_scores_gemma":[0.000253974,0.0002352479,0.0002005069,0.000245582,0.0002994824,0.0002158218,0.0001836331,0.0002643379,0.0002358235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531873,"about_ca_system_score_gemma":0.000173234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004317549,"about_ca_topic_score_gemma":0.003414563,"domain_scores_codex":[0.9999222,0.00002027744,0.000003780387,0.00002327305,0.00001148615,0.00001897197],"domain_scores_gemma":[0.9998185,0.00003204865,0.0000491269,0.00003246609,0.00002606966,0.00004181534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03806609,0.0006731748,0.1690369,0.0001105488,0.0004519126,0.0007574958,0.0006580528,0.0004488119,0.7636653,0.0005125084,0.0002870456,0.02533217],"study_design_scores_gemma":[0.0001497311,0.003246686,0.8861096,0.000009679059,0.0001952188,0.001057425,0.0004948686,0.0006471188,0.1063354,0.0002870406,0.001443358,0.00002395746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988965,0.0003681641,0.0001591456,0.00001664516,0.000004082754,0.00000407523,0.0001092719,0.000006170132,0.0004359949],"genre_scores_gemma":[0.998399,0.0002617965,0.0001032324,0.00001622128,0.000003110298,0.000006677611,0.0002108639,0.000006146508,0.0009929639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004317549,"threshold_uncertainty_score":0.008584857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01529553149855565,"score_gpt":0.2970649011521889,"score_spread":0.2817693696536332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}