{"id":"W4207067430","doi":"10.1016/s1473-3099(21)00469-2","title":"Combining baloxavir marboxil with standard-of-care neuraminidase inhibitor in patients hospitalised with severe influenza (FLAGSTONE): a randomised, parallel-group, double-blind, placebo-controlled, superiority trial","year":2022,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Public Health Ontario; University of Toronto; University Health Network","funders":"Sanofi Pasteur; bioMérieux; Astellas Pharma Canada; Meso Scale Diagnostics; F. Hoffmann-La Roche; Roche; Biomedical Advanced Research and Development Authority; GlaxoSmithKline","keywords":"Neuraminidase inhibitor; Medicine; Placebo; Double blind; Randomized controlled trial; Neuraminidase; Placebo-controlled study; Internal medicine; Anesthesia; Virology; Coronavirus disease 2019 (COVID-19); Pathology; Virus; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001988985,0.002323526,0.006432276,0.0005731133,0.0005153202,0.001532071,0.001405733,0.00299393,0.006278461],"category_scores_gemma":[0.002670188,0.001109988,0.003743412,0.0005140888,0.001612733,0.001851814,0.0006097038,0.003930957,0.00118169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008066953,"about_ca_system_score_gemma":0.0008474645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126342,"about_ca_topic_score_gemma":0.00209104,"domain_scores_codex":[0.9989761,0.0005006955,0.00009517089,0.0001789393,0.00006908448,0.000180047],"domain_scores_gemma":[0.9989036,0.0004015731,0.0001972139,0.00009176704,0.00007716056,0.0003287069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9909878,0.001194868,0.0001383484,0.0006889601,0.0007243254,0.00002281927,0.00002420224,0.00008488306,0.0008178218,0.0000406652,0.0001907121,0.005084639],"study_design_scores_gemma":[0.9723958,0.02617437,0.0005236167,0.00003673401,0.0003905717,0.00001413035,0.00001680568,0.0001249983,0.0001001525,0.00005457595,0.0001567759,0.00001144133],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733182,0.01767631,0.0008351834,0.001041991,0.002162264,0.002065923,0.0006996207,0.0001704053,0.002030023],"genre_scores_gemma":[0.9850333,0.006630671,0.001340446,0.001229061,0.0009488934,0.001832473,0.0006367635,0.00002601157,0.002322352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006432276,"threshold_uncertainty_score":0.02100354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066605151313044,"score_gpt":0.3128397913860043,"score_spread":0.2821737398728738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}