{"id":"W4207067430","doi":"10.1016/s1473-3099(21)00469-2","title":"Combining baloxavir marboxil with standard-of-care neuraminidase inhibitor in patients hospitalised with severe influenza (FLAGSTONE): a randomised, parallel-group, double-blind, placebo-controlled, superiority trial","year":2022,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Public Health Ontario; University of Toronto; University Health Network","funders":"Sanofi Pasteur; bioMérieux; Astellas Pharma Canada; Meso Scale Diagnostics; F. Hoffmann-La Roche; Roche; Biomedical Advanced Research and Development Authority; GlaxoSmithKline","keywords":"Neuraminidase inhibitor; Medicine; Placebo; Double blind; Randomized controlled trial; Neuraminidase; Placebo-controlled study; Internal medicine; Anesthesia; Virology; Coronavirus disease 2019 (COVID-19); Pathology; Virus; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007249544,0.0005192456,0.001985451,0.0003101066,0.0006671912,0.00008521295,0.0003385868,0.00007985598,0.0001116358],"category_scores_gemma":[0.0004842277,0.000323303,0.0002796683,0.0007912742,0.0004638323,0.0002900703,0.0003381262,0.0008903348,0.000004683889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006539737,"about_ca_system_score_gemma":0.0006640995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003348956,"about_ca_topic_score_gemma":0.0001781091,"domain_scores_codex":[0.9955251,0.0007252518,0.0007515287,0.000570774,0.001615816,0.0008115545],"domain_scores_gemma":[0.9974111,0.0006908231,0.0004009679,0.000794098,0.0004554913,0.0002475121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6470087,0.0009421519,0.3481142,0.0002347352,0.0005251921,0.00007693961,0.001569213,0.001074329,0.000006772115,0.00005332049,0.0001049262,0.0002895407],"study_design_scores_gemma":[0.9366356,0.01713509,0.04208054,0.0002175714,0.0006661512,0.00001534077,0.001829356,0.00003497132,0.00002542278,0.00002770238,0.0009083985,0.0004238807],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852559,0.001251964,0.000003992204,0.0001737236,0.0002015764,0.01126698,0.0004622512,0.0002037582,0.001179835],"genre_scores_gemma":[0.9938574,0.0000668112,0.00002498276,0.0007442058,0.0002798141,0.004791637,0.000131008,0.00007821834,0.00002585041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3060336,"threshold_uncertainty_score":0.9999219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066605151313044,"score_gpt":0.3128397913860043,"score_spread":0.2821737398728738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}