{"id":"W4210244930","doi":"10.1053/j.gastro.2022.01.047","title":"Guselkumab for the Treatment of Crohn’s Disease: Induction Results From the Phase 2 GALAXI-1 Study","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Janssen Research and Development; Janssen Scientific Affairs","keywords":"Crohn's disease; Medicine; Phase (matter); Internal medicine; Gastroenterology; Disease; Dermatology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321788,0.0001817653,0.000268892,0.00004588042,0.0006079934,0.000006450996,0.0003080749,0.00004307336,0.0002797621],"category_scores_gemma":[0.0000334079,0.0001033418,0.000187839,0.00006959674,0.0001445986,0.0000257083,0.00007479634,0.00009346537,0.00001459909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008534623,"about_ca_system_score_gemma":0.00003323784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000346773,"about_ca_topic_score_gemma":0.0002540816,"domain_scores_codex":[0.9982867,0.0006684948,0.0003424268,0.0003487518,0.00004647019,0.0003071756],"domain_scores_gemma":[0.9986748,0.0004885535,0.0002142724,0.0005682466,0.00003540554,0.00001876233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2917591,0.04113504,0.3820896,0.000009427674,0.01337608,0.0001189739,0.02747715,0.00056364,0.02068869,0.0001287832,0.03702632,0.1856271],"study_design_scores_gemma":[0.04299318,0.01777895,0.8706033,0.00000288127,0.001722964,0.00002674241,0.004387678,0.00001872311,0.001227944,0.00008511492,0.06103579,0.0001166904],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905168,0.001705995,0.00005978483,0.001525638,0.00169761,0.001340534,0.003116623,0.00002908017,0.00000789793],"genre_scores_gemma":[0.9968928,0.0001119009,0.00001302044,0.0001229839,0.0001187149,0.001245599,0.0009802268,0.00001461228,0.000500217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4885137,"threshold_uncertainty_score":0.4676255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133859218263738,"score_gpt":0.2714282160265477,"score_spread":0.2400896238439103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}