{"id":"W4210245365","doi":"10.1016/j.antiviral.2022.105254","title":"5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis","year":2022,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Key Research and Development Program of China; Chinese Academy of Meteorological Sciences; Fundamental Research Funds for the Central Universities; Beijing Municipal Commission of Education; National Natural Science Foundation of China","keywords":"Virology; Biology; Coronavirus; RNA-dependent RNA polymerase; RNA polymerase; RNA; Genetics; Disease; Gene; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004778,0.0002714101,0.0005251742,0.001172084,0.0009540788,0.0001328086,0.0007372926,0.0001399969,0.00008876053],"category_scores_gemma":[0.00219766,0.0002534828,0.000271924,0.002560596,0.0004742662,0.0002237853,0.001414334,0.002219168,0.001694164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005661048,"about_ca_system_score_gemma":0.001035219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302212,"about_ca_topic_score_gemma":0.00007758931,"domain_scores_codex":[0.992641,0.001038221,0.0004235906,0.00085904,0.003499293,0.001538829],"domain_scores_gemma":[0.9973479,0.001147448,0.0000528332,0.0009560444,0.0004442909,0.00005149438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009125493,0.0005069725,0.009430327,0.0001171479,0.00008513916,0.0009080898,0.0003516019,4.873098e-8,0.9368797,0.0007237913,0.02318358,0.02690104],"study_design_scores_gemma":[0.0008212831,0.0006611656,0.001189239,0.00006350346,0.00001969741,0.00007106642,0.0006004492,0.0002464079,0.8381047,0.0003920588,0.1576111,0.0002193583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9177799,0.0005151863,0.00001109043,0.002149651,0.0001315947,0.0008161154,0.00003353551,0.0001325049,0.07843047],"genre_scores_gemma":[0.9870898,0.00002435798,0.00007144061,0.01100899,0.0002875868,0.0004897988,0.000006705385,0.00008985172,0.0009314294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1344275,"threshold_uncertainty_score":0.9999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1421353236957363,"score_gpt":0.4268978804641974,"score_spread":0.2847625567684611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}