{"id":"W4210248179","doi":"10.1002/alz.050660","title":"Development of a therapeutic approach for hereditary diseases with prime editing: A study on Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Genome editing; HEK 293 cells; Sanger sequencing; Mutation; Induced pluripotent stem cell; Biology; Computational biology; Amyloid precursor protein; Molecular biology; Gene; Genetics; CRISPR; Alzheimer's disease; Disease; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006695971,0.0005991,0.0006676781,0.0003853278,0.0002655352,0.0005385148,0.0004145334,0.0006455468,0.001314269],"category_scores_gemma":[0.0002505102,0.0001086625,0.0007463878,0.0002390282,0.0004367462,0.0005463585,0.0003185424,0.001072622,0.0002845736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647387,"about_ca_system_score_gemma":0.0002738997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002195771,"about_ca_topic_score_gemma":0.0002275598,"domain_scores_codex":[0.9998015,0.0000656933,0.00001368039,0.00005201762,0.00003463845,0.0000324923],"domain_scores_gemma":[0.999913,0.00002567631,0.00001144438,0.00001167694,0.00001652707,0.00002166773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00224117,0.004545161,0.0011308,0.002910021,0.0002888806,0.001178337,0.0003417889,0.0005513416,0.6924697,0.005914088,0.003543213,0.2848855],"study_design_scores_gemma":[0.003241361,0.06561785,0.01410087,0.000978649,0.002293689,0.01239253,0.000418772,0.003251724,0.6143672,0.005846461,0.2773542,0.0001366929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6657591,0.2805842,0.03210603,0.003848237,0.001503123,0.000916535,0.0003949679,0.0003051932,0.01458263],"genre_scores_gemma":[0.7653226,0.1952883,0.02604071,0.002661731,0.0008216386,0.001047183,0.0006223419,0.00009489423,0.008100648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314269,"threshold_uncertainty_score":0.004396737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377580169789245,"score_gpt":0.2946177443493287,"score_spread":0.2708419426514363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}