{"id":"W4210254172","doi":"10.3390/v14020273","title":"High Level of Pre-Treatment HIV-1 Drug Resistance and Its Association with HLA Class I-Mediated Restriction in the Pumwani Sex Worker Cohort","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"George & Fay Yee Centre for Healthcare Innovation; Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Max Rady College of Medicine, University of Manitoba; University of Manitoba; Manitoba Medical Service Foundation","keywords":"Human leukocyte antigen; Drug resistance; Integrase; Allele; Medicine; Cohort; Immunology; Population; Antiretroviral therapy; Human immunodeficiency virus (HIV); Gene; Biology; Virology; Viral load; Genetics; Internal medicine; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000434428,0.0002565743,0.000160908,0.000578854,0.000798725,0.000534868,0.0003975576,0.0003902503,0.003702983],"category_scores_gemma":[0.001152581,0.0002818835,0.000161338,0.0003902179,0.0003100726,0.000284946,0.0003458018,0.0005068591,0.0002573632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918755,"about_ca_system_score_gemma":0.0002501837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005667594,"about_ca_topic_score_gemma":0.006589849,"domain_scores_codex":[0.9997631,0.00005235224,0.00001309679,0.00005966624,0.00004834745,0.00006337401],"domain_scores_gemma":[0.9996077,0.00005270023,0.0001609272,0.00004522684,0.00003887225,0.0000946608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001154992,0.00002903559,0.997806,0.000005190239,0.00001666337,0.000135279,0.0002255534,0.00000676056,0.0006621165,0.00001917913,0.00007717626,0.0009015099],"study_design_scores_gemma":[0.000007207584,0.00009205686,0.9983003,0.000004660885,0.0000155802,0.0007285333,0.0004485595,0.00006378046,0.0001213872,0.00001620471,0.0001990291,0.0000029234],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996744,0.00004331631,0.00002587213,0.00002100818,0.000001657394,0.000004347454,0.00006103682,0.000001181647,0.0001671448],"genre_scores_gemma":[0.9997732,0.0000268999,0.00003224804,0.000009438559,0.000002650829,0.000004743725,0.00004405813,8.424835e-7,0.0001059101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005667594,"threshold_uncertainty_score":0.01238769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779437296411999,"score_gpt":0.2585526450482999,"score_spread":0.2307582720841799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}