{"id":"W4210257644","doi":"10.3390/curroncol29020045","title":"Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"DPYD; Genotyping; Medicine; Mucositis; Internal medicine; Oncology; Chemoradiotherapy; Gastroenterology; Pharmacogenetics; Chemotherapy; Genotype; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004058601,0.0004055175,0.0005834828,0.0003499323,0.0002951374,0.0008954727,0.0004756831,0.0005272756,0.0006511401],"category_scores_gemma":[0.004864854,0.0001997388,0.0006707783,0.0006880646,0.0003768385,0.0005728288,0.0003011049,0.0005567194,0.0001549245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004798666,"about_ca_system_score_gemma":0.0008184556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00285705,"about_ca_topic_score_gemma":0.00181585,"domain_scores_codex":[0.9987707,0.0005497027,0.0001291628,0.000199674,0.0002110799,0.0001396907],"domain_scores_gemma":[0.9931582,0.002748596,0.001962974,0.0008670334,0.0007715288,0.0004916296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003445884,0.0004654821,0.9023603,0.0001300667,0.0003413014,0.0002250643,0.0002240616,0.0003361584,0.004400232,0.00003406632,0.0003545648,0.08768281],"study_design_scores_gemma":[0.0000753846,0.002643412,0.9927169,0.00004748665,0.0004328376,0.0005821381,0.0001146963,0.0005374609,0.001473052,0.00003477705,0.001324728,0.00001713347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945889,0.003914831,0.0008810277,0.0001953131,0.00002161432,0.00003336211,0.00009276653,0.00001568985,0.0002565517],"genre_scores_gemma":[0.9955968,0.002304415,0.001257958,0.0001345763,0.00008481432,0.00002172273,0.0004160006,0.000010257,0.0001733919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004058601,"threshold_uncertainty_score":0.02146417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09478164028403838,"score_gpt":0.3797786608036613,"score_spread":0.2849970205196229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}