{"id":"W4210258089","doi":"10.1101/2022.01.25.22269841","title":"Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; UK Dementia Research Institute; Instituto Serrapilheira; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; EU Joint Programme – Neurodegenerative Disease Research; National Alliance for Research on Schizophrenia and Depression; Alzheimerfonden; Weston Brain Institute; International Society for Neurochemistry; Gun och Bertil Stohnes Stiftelse; BrightFocus Foundation; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Cerveau Technologies; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; McGill University; Demensförbundet; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Astrogliosis; Glial fibrillary acidic protein; Biomarker; Cerebrospinal fluid; Pathology; Astrocyte; Amyloid (mycology); Positron emission tomography; Neuroscience; Alzheimer's disease; Medicine; Psychology; Disease; Biology; Central nervous system; Immunohistochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003404209,0.0002512172,0.0003174123,0.0005366832,0.0001691391,0.0004491093,0.00007778019,0.0001915051,0.0006664222],"category_scores_gemma":[0.0005394969,0.0001132294,0.0001737226,0.0003717067,0.000177706,0.0001606775,0.000244927,0.0001357259,0.000134218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001387275,"about_ca_system_score_gemma":0.0001361916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167398,"about_ca_topic_score_gemma":0.001724769,"domain_scores_codex":[0.9998962,0.00002980943,0.00001180306,0.00002059492,0.00002845334,0.00001309306],"domain_scores_gemma":[0.999803,0.00002670929,0.00007950616,0.00001575471,0.0000501974,0.00002491119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001846902,0.0001400537,0.8969609,0.0001041934,0.0002338709,0.0006922585,0.000536132,0.000818492,0.07880386,0.0003159223,0.0004423104,0.01910505],"study_design_scores_gemma":[0.00001780339,0.0001970131,0.9881137,0.00001263228,0.00006863561,0.00114935,0.0003595376,0.001336001,0.007487576,0.0007091014,0.0005405516,0.000008120651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988926,0.0003001627,0.0003242263,0.0000265229,0.00000292874,0.000003693539,0.0001552754,0.000005941135,0.0002886768],"genre_scores_gemma":[0.9991639,0.000128511,0.0003611369,0.00001038541,0.000003394725,0.000003742576,0.0001430818,0.00000203854,0.000183754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167398,"threshold_uncertainty_score":0.003328502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05192731883808845,"score_gpt":0.3396831347920949,"score_spread":0.2877558159540065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}