{"id":"W4210268453","doi":"10.1016/j.jmb.2022.167462","title":"Adventures on the Routes of Protein Evolution—In Memoriam Dan Salah Tawfik (1955–2021)","year":2022,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Fondazione Italiana per la Ricerca sul Cancro","keywords":"Protein engineering; Promiscuity; Protein function; Protein stability; Function (biology); Computational biology; Adventure; Directed evolution; Biology; Evolutionary biology; Computer science; Enzyme; Genetics; Biochemistry; Ecology; Gene; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638805,0.001175586,0.0008905029,0.001579165,0.0005732108,0.001835746,0.001116441,0.002448195,0.004338568],"category_scores_gemma":[0.002280503,0.0003546388,0.0005599916,0.001422616,0.001736581,0.00406659,0.002540486,0.005261796,0.003374086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00146875,"about_ca_system_score_gemma":0.001531416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968725,"about_ca_topic_score_gemma":0.002425854,"domain_scores_codex":[0.999612,0.00006968866,0.00004318426,0.00009050078,0.0001353009,0.00004943244],"domain_scores_gemma":[0.9992788,0.0003207074,0.00006481838,0.00002208251,0.0001798659,0.0001337432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001277902,0.00003372371,0.0001407193,0.00252184,0.00005866434,0.0002110083,0.000121226,0.0002875598,0.0004762094,0.01312895,0.6530677,0.3298246],"study_design_scores_gemma":[0.000008368599,0.00001522846,0.0001651519,0.0006065861,0.000009499031,0.0002180853,0.00001846195,0.00002189803,0.00009026365,0.002348894,0.9964889,0.000008747388],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007492452,0.9422788,0.0002348088,0.01446698,0.04121257,0.000003950781,0.00004056534,0.00001258839,0.001674838],"genre_scores_gemma":[0.002189188,0.9130849,0.0005083146,0.01950781,0.05562594,0.00002070065,0.0001155712,0.00002295752,0.008924612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004338568,"threshold_uncertainty_score":0.01451391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271350333840247,"score_gpt":0.2951723427393757,"score_spread":0.2824588394009732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}